Phase 3 Pulmonary Hypertension Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You must be willing to sign and date a consent form agreeing to take part in the study
- You must be willing to follow all study procedures and be available for the full length of the study
- You must be 18 years old or older
- You must have been diagnosed with a heart, lung, or blood vessel disease that puts you at risk of developing scarring in your body tissues (known as fibrosis)
- You must have already had a CT scan of your chest (lungs, heart, and/or blood vessels) at some point before joining
- You must be able to lie still in a PET/CT scanner for up to 45 minutes
- If you are a woman who could become pregnant, you must have been using a highly effective form of birth control for at least 1 month before the study starts, and agree to continue using it throughout the study and for 4 weeks after your last scan
- If you are a man who could father a child, you must agree to use condoms or another effective form of birth control during the study and for 4 weeks after your last scan
Who may not be able to join:
- People who have had allergic reactions to substances similar to the study imaging agent (18F-FAPI-74) or other materials used in the study
- People with ongoing illnesses, personal circumstances, or other factors that would make it difficult to follow the study requirements
- People who are currently pregnant or breastfeeding
- Women who could become pregnant or men who are actively trying to have a child and are unwilling to use effective birth control during the study and for 4 weeks after the last scan
- People with severe claustrophobia (fear of enclosed spaces) that does not improve with anti-anxiety medication taken by mouth
- People who weigh more than 350 lbs or who cannot physically fit inside the imaging scanner
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Anthony F Suffredini, M.D., National Heart, Lung, and Blood Institute (NHLBI)
Phone: (301) 402-3484
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
To compare 18F-FAPI-74 PET/CT to standard of care imaging (non-contrast chest CT and 18F-FDG-PET/CT, cardiac MRI for heart cohort) to detect fibrosis.
Can't join this trial?
Data last synced from ClinicalTrials.gov: 19 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.