Prostate Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with prostate cancer (a specific type called adenocarcinoma) that is contained within the prostate, confirmed through a biopsy guided by MRI and ultrasound imaging
• People whose cancer is at a specific stage (T2cN0M0, meaning the cancer is in the prostate only with no spread to lymph nodes or other parts of the body; a finding of early local extension called T3a on scans is also permitted)
• People who have had a prostate MRI scan at New York-Presbyterian Hospital within the past 6 months, showing a specific area of concern rated at suspicion level 2 using a standardised scoring system called PI-RADS version 2.0
• People whose biopsy included at least 10 standard tissue samples plus 2 targeted samples from the MRI-identified area, with results confirming a specific cancer grade known as Gleason score 4+3 on one side of the prostate only
• People between 40 and 85 years of age
• People who have chosen to pursue focal therapy (a targeted treatment) and have decided against other treatment options such as active surveillance, surgery, radiation, cryosurgery, or hormone therapy
• People who have given their signed agreement to take part in the study

Who may not be able to join:

• People who have a Gleason score 4+4 cancer found outside the area identified on MRI
• People who have calcium deposits in the prostate that the trial doctor believes would interfere with delivering the treatment energy to the tumour (relevant to those choosing a treatment called HIFU)
• People with any medical condition that the trial team believes would make it unsafe for them to take part
• People with a high-risk anaesthesia rating (classified as level IV or above under a standard medical scoring system used by anaesthesiologists)
• People who currently have a urinary tract infection
• People who have any structural problems in the rectum, such as tears, scarring, narrowing, or other abnormalities that would prevent insertion of the treatment device
• People with active inflammatory bowel disease that is not under control
• People who have an abnormal passageway (fistula) between the urinary tract or rectum and another part of the body
• People who have previously had certain surgeries involving a urethral sling, artificial urinary sphincter, or penile prosthesis
• People for whom MRI scanning is not safe or suitable, such as those with a contrast dye allergy, severe claustrophobia, or a medical implant that is not compatible with MRI

Important: Always verify eligibility with the trial site directly before applying.