Phase 2 Macular Degeneration Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 50 years old or older at the time of your first screening visit
• You are willing to use an acceptable form of birth control during the trial
• You have been diagnosed with abnormal blood vessel growth behind both eyes (a condition called bilateral CNV) caused by wet age-related macular degeneration (wet AMD) in both eyes
• Your vision (measured using a standard eye chart test) falls within a specific range required by the trial, depending on whether you have previously received the study treatment (Ixo-vec) or not (confirm with trial site for exact vision requirements)
• You have a history of prior treatment with anti-VEGF injections (a common wet AMD treatment), and if applicable, prior exposure to the study treatment Ixo-vec, in line with the trial's requirements
• Your eyes have shown a meaningful positive response to anti-VEGF injections, as defined by the trial (confirm with trial site)
• You are able and willing to follow all study procedures as judged by the study doctor

Who may not be able to join:

• You have a serious health condition, illness, or abnormal test result that could make the study treatment unsafe for you or make it hard to participate, including — in some cases — a history of severe COVID-19 (confirm with trial site)
• You have previously received any gene therapy other than Ixo-vec (if Ixo-vec applies to you)
• You are currently taking steroid medications that affect the relevant eye or eyes at the time of your first screening visit
• You have received another investigational treatment or medical device in the relevant eye within the past 3 months
• You have a known allergy or bad reaction to any of the products or ingredients used in this trial
• You have poorly controlled diabetes or a blood sugar control measurement (HbA1c) of 8.0% or higher
• You have a history of certain heart or blood vessel diseases, or ongoing bleeding disorders (confirm with trial site for specifics)
• You have taken immune-suppressing medications within a certain period before the trial (confirm with trial site for exact timeframe)
• You have received systemic (whole-body) anti-VEGF treatment within a certain period before the trial (confirm with trial site for exact timeframe)
• You have been diagnosed with cancer within the past 5 years, unless it has been fully and adequately treated as defined by the trial
• You have an active infection in or around the relevant eye or eyes
• You have another eye condition in the relevant eye (beyond wet AMD) that could affect your vision, interfere with assessments, or require treatment during the trial
• You have had certain prior eye surgeries or treatments that could affect the trial results or increase your risk (confirm with trial site for specifics)
• You have a history of a detached retina or a tear in the layer beneath your retina in the relevant eye
• You have uncontrolled high pressure in your eye or uncontrolled glaucoma, as defined by the trial
• You have a history of significant inflammation inside the eye (specifically, inflammatory cells rated 2+ or higher) in certain eyes, which may increase the risk of eye inflammation (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.