Pulmonary Hypertension Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with a type of bile duct cancer called intrahepatic cholangiocarcinoma (ICC), confirmed by a tissue biopsy, and had surgery to remove it within the past 12 weeks with the goal of curing the disease.
• Your cancer has not spread to distant parts of the body (no distant metastasis), regardless of the original tumor size or whether nearby lymph nodes were affected.
• You have at least one feature that puts you at higher risk of the cancer returning — such as: the tumor had grown through the surface of the liver or into nearby structures before surgery; scans showed multiple tumors or a single tumor larger than 5 cm; there was evidence of cancer in blood or lymph vessels; or cancer was found in nearby lymph nodes.
• You have not had any previous systemic (whole-body) treatment for this cancer.
• You are reasonably active and able to carry out daily activities (your doctor will assess this using a standard scale called ECOG, scoring 0–2).
• Your doctor expects you to live for at least 3 more months.
• Your heart, liver, kidneys, and other organs are working well enough to handle treatment.
• You are willing to use reliable contraception (or have had surgical sterilisation) during the study and for 120 days after your last dose of treatment.
• You are willing to sign a consent form and are expected to be able to follow the study requirements.

Who may not be able to join:

• You have taken medication that suppresses the immune system in the 28 days before joining (not including low-dose steroid creams, inhalers, or very low-dose oral steroids).
• You have taken certain herbal or immune-boosting treatments (such as thymosin or interferons) in the past 4 weeks.
• You have serious heart problems that are not well controlled, such as recent heart attack, unstable chest pain, certain irregular heartbeats, severe heart failure, or poor heart pumping function.
• You have had a serious active infection recently requiring intravenous antibiotics or antivirals, a fever above 38.5°C in the past 4 weeks, or major surgery in the past 3 weeks.
• You have an active autoimmune condition (where your immune system attacks your own body) or immune deficiency disease — for example, active hepatitis, lung inflammation, or rheumatoid arthritis — with some exceptions such as well-controlled thyroid disease or well-controlled Type 1 diabetes (confirm with trial site).
• You have HIV/AIDS, or active hepatitis B (with virus levels above a certain threshold) or active hepatitis C, unless your hepatitis B is well controlled on antiviral treatment for at least 14 days.
• You have had, or are planned to have, an organ transplant (corneal eye grafts are an exception).
• You are currently taking part in another clinical trial involving an experimental treatment, or have done so recently without fully recovering from any side effects.
• You are known to be allergic to any of the ingredients in the study drug.
• You have had, or are planned to have, a bone marrow or stem cell transplant from another person.
• You have a mental health condition or substance use problem that is not well controlled.
• You have high blood pressure that remains at 140/90 mmHg or above even with treatment.
• You have had significant bleeding in your digestive system in the past 3 months, or a blood clot event (such as a stroke, deep vein thrombosis, or pulmonary embolism) in the past 6 months.
• You have a blood clotting disorder or are taking blood-thinning medication.
• You have significant levels of protein in your urine (confirm with trial site).
• Your doctor considers you unsuitable for other medical reasons not listed here.

Important: Always verify eligibility with the trial site directly before applying.