Alzheimer's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with probable Alzheimer's disease (AD) with mild cognitive impairment, based on 2024 guidelines, OR you have been diagnosed with a type of frontotemporal dementia (a condition affecting behaviour or language).
• Test results (from a brain scan or spinal fluid test) show abnormal amyloid protein buildup in the brain — this is a marker linked to Alzheimer's disease (confirm with trial site).
• Test results (from a brain scan or spinal fluid test) show abnormal tau protein in the brain — another marker linked to Alzheimer's disease (confirm with trial site).
• If you have Alzheimer's disease, you have been taking standard Alzheimer's medications at the same dose for at least 12 weeks before the study starts.
• If available, genetic test results confirming a frontotemporal dementia-related gene mutation may be included (this appears to be optional — confirm with trial site).
• You are between 45 and 85 years old; there is no restriction on gender.
• You are right-handed.
• You have had at least 3 years of formal education.
• You scored 11 or higher on a standard memory and thinking test called the MMSE (confirm with trial site).
• You have a CDR score of 1 or 2, meaning your dementia is in the mild to moderate range (confirm with trial site).
• You have a reliable caregiver who can support your participation.
• You are able to take part in thinking and memory tests and training activities.
• You fully understand the study, are willing to take part voluntarily, and can sign a consent form approved by an ethics committee.

Who may not be able to join:

• You have been diagnosed with another type of dementia or a major brain or nervous system condition, such as stroke, epilepsy, Lewy body dementia, vascular dementia, Parkinson's disease dementia, or Huntington's disease.
• You have a significant mental health condition, such as severe depression or severe anxiety.
• You have serious problems with your heart, liver, or kidneys (for example, advanced heart failure, liver cirrhosis, or kidney failure).
• You take medications that are known to significantly affect memory or thinking (such as certain sedatives or specific bladder medications), unless your doctor has approved them.
• You have metal implants in your body that are not safe for MRI scans or a specific type of brain stimulation used in this trial, such as a pacemaker or deep brain stimulator.
• You have defects or abnormalities in your skull.
• You are unable to tolerate wearing an EEG cap (brain activity recording device) or keeping your head still during procedures.
• You have severe vision or hearing problems that would prevent you from completing the study tasks.
• You have a history of alcohol or drug misuse.
• You have taken part in another clinical trial within the past 3 months.
• You are currently receiving or have recently received treatment with certain newer Alzheimer's drugs called anti-amyloid antibodies (for example, lecanemab or donanemab).

Important: Always verify eligibility with the trial site directly before applying.