Phase 2 Motor Neurone Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with ALS (also known as Lou Gehrig's disease) using a specific set of medical guidelines called the Gold Coast criteria.
• Your ALS symptoms started less than 36 months (3 years) before the study screening visit.
• Your lungs are working at 50% or more of the expected level for a person of your age and size, based on a breathing test.
• Your body weight falls within a healthy range — specifically, your Body Mass Index (BMI) is between 18 and 40 (confirm with trial site if unsure of your BMI).

Who may not be able to join:

• You have a significant medical condition that, in the doctor's opinion, could affect your safety, interfere with the study results, or make it unlikely you would be able to complete the trial.
• You have a history of abnormalities in the brain or spine, seen on an MRI or CT scan, that could make certain procedures (such as a lumbar puncture, or "spinal tap") unsafe or complicated.
• You have previously received certain types of advanced treatments, including antisense oligonucleotide therapy, gene-silencing therapy (siRNA), stem cell therapy, or gene therapy, for any condition.
• You have had a tracheostomy (a surgical opening in the throat to help with breathing).
• You currently have or have had HIV, Hepatitis B, or Hepatitis C infection.
• You have an implanted device that drains fluid from the brain or spine, or an implanted vascular (blood vessel) device.
• You have a condition that puts you at risk of uncontrolled bleeding.
• You are currently pregnant or breastfeeding.

Important: Always verify eligibility with the trial site directly before applying.