Phase 3 Glaucoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 19 years of age or older
• You have been diagnosed with a type of glaucoma called primary open-angle glaucoma, or with higher-than-normal eye pressure (ocular hypertension)
• You are currently using, or have previously used, a combination of three eye pressure-lowering medications, OR a combination of two specific medications (dorzolamide and a topical beta-blocker), OR your current treatment is not controlling your eye pressure well enough and your doctor feels you may benefit from a three-medication combination
• You have stopped taking your previous glaucoma medications for a specific waiting period before the study starts (the length of time depends on which medications you were taking — confirm with trial site)
• Your eye pressure measures 21 mmHg or higher in at least one eye at a specific morning measurement at the start of the study
• You are able to understand and willingly sign a consent form agreeing to take part

Who may not be able to join:

• You have a severe loss of central vision as measured by a specific eye test
• You have a chronic, recurring, or serious inflammatory eye disease, such as severe eye inflammation or a herpes eye infection
• Your best corrected vision (even with glasses or contacts) is below a certain level in both eyes at two separate visits
• You have any condition that makes it impossible to accurately measure your eye pressure
• You have another eye condition that, in the doctor's opinion, makes it unsafe to use the study medication (for example, severe dry eye)
• You need additional eye pressure-lowering medications beyond what the study provides
• You have asthma, a history of asthma, bronchospasm, or severe chronic lung disease
• You have certain heart conditions, such as a very slow heart rate, specific types of heart block, heart failure, cardiogenic shock, or related conditions
• You have severe kidney problems or a specific blood chemistry imbalance (confirm with trial site)
• You have an untreated tumour of the adrenal gland called pheochromocytoma
• You have any other serious illness that the investigator feels makes participation unsafe
• You had eye injury or eye surgery within the past 24 weeks (note: cataract surgery done more than 8 weeks ago may still be acceptable — confirm with trial site)
• You had an eye infection or eye inflammation within the past 12 weeks (or within 8 weeks for simple conjunctivitis)
• You had laser eye surgery within the past 12 weeks
• You took oral beta-blocker medications within the past 4 weeks
• Certain blood pressure medications were added or changed within the past 4 weeks, unless the dose has been stable for at least 7 days before your screening visit
• You took certain medications affecting the nervous system (such as MAO inhibitors, certain antidepressants, or alpha-adrenergic agonists) within the past 2 weeks
• You used steroid eye drops or creams around the eye within the past 2 weeks
• You used oral or systemic steroids within the past 4 weeks
• You had a steroid injection into or around the eye within the past 24 weeks
• You need to wear contact lenses during the study
• You have a known allergy to any ingredient in the study medication or to eye drops used for diagnosis
• You have taken part in another clinical drug or device trial within the past 4 weeks
• You are currently pregnant or breastfeeding
• You are a woman or man who could potentially have children and are unwilling to use an acceptable form of contraception during the study, or you plan to become pregnant during the study (acceptable methods include hormonal contraceptives, an IUD/IUS, surgical sterilisation, or complete abstinence — confirm with trial site for full details)

Important: Always verify eligibility with the trial site directly before applying.