Phase 1 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are able to understand and willing to sign the consent form and follow the study procedures
• You are female and aged 18 or older at the time of signing consent
• You have been diagnosed (confirmed by lab testing of tissue) with a specific type of ovarian, fallopian tube, or peritoneal cancer (high-grade serous or similar high-grade type)
• Your cancer was classified as Stage III or IV when first diagnosed
• You had surgery to remove as much of the cancer as possible, leaving no more than 1 cm of remaining tumour
• You have completed a first course of platinum-based chemotherapy (at least 4 cycles of carboplatin and paclitaxel, or a similar treatment, given before and/or after surgery)
• After chemotherapy, your cancer either showed a complete or partial response, or showed no signs of getting worse, based on scans assessed by your doctor
• Your last dose of first-line chemotherapy was at least 4 weeks ago but no more than 12 weeks ago at the time of screening
• There is no sign that your cancer has come back or grown between finishing chemotherapy and your screening visit
• Your cancer has been tested and confirmed as BRCA wildtype (a specific genetic result) and HRP (homologous recombination proficient — confirm with trial site)
• You have not had, and are not currently having or planning to have, bevacizumab or a PARP inhibitor as a maintenance treatment after first-line chemotherapy
• Your general health and ability to carry out daily activities meets a specific standard (ECOG score of 0 or 1 — confirm with trial site)
• Your blood counts and organ function (such as liver and kidneys) are within acceptable ranges
• If you are able to become pregnant, you have had a negative pregnancy test
• Your immune system tissue type (HLA type) matches the study's specific requirements (confirm with trial site)

Who may not be able to join:

• You have a type of ovarian tumour that is non-epithelial or considered low risk/borderline
• You have uncontrolled fluid build-up around your abdomen or lungs that needed draining within the last 4 weeks before screening
• You have another active cancer, or have had another cancer in the past 3 years (with some exceptions for very low-risk cancers — confirm with trial site)
• You have an active autoimmune disease (where your immune system attacks your own body) that requires ongoing medication to suppress your immune system
• You have another serious illness that, in the doctor's opinion, could put you at risk or affect how the study is carried out
• You have had a severe allergic reaction (anaphylaxis) to a type of treatment called mRNA-LNP therapy (such as certain vaccines — confirm with trial site)
• You have previously received a cancer vaccine, a checkpoint inhibitor, or a cell-based cancer therapy
• You have received any vaccine in the 30 days before your first dose in the study
• You have taken part in another clinical trial involving an experimental medicine in the past 90 days (or longer, depending on the drug — confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.