Phase 2 Alzheimer's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are aged 50 or older at the time of joining the trial
• People who have received a confirmed diagnosis from a neurologist or geriatric psychiatrist of Alzheimer's disease, frontotemporal dementia with signs of brain inflammation, dementia with Lewy bodies with certain inflammation markers, or another neurodegenerative dementia where inflammation in the brain has been confirmed
• People whose score on a standard memory and thinking test (called the MoCA) falls between 10 and 25, indicating mild to moderate cognitive impairment
• People who are reasonably physically functional, as measured by standard performance scales used by doctors (confirm with trial site)
• People who are medically stable and assessed by a radiation specialist as able to safely receive radiation therapy
• People who have a reliable carer or close contact who is able to attend at least 80% of the scheduled appointments with them
• People (or their legal representative) who are able to give written consent to participate; a carer's co-consent is also required
• People whose doctor estimates they have a life expectancy of at least 18 months
• People who are willing and able to attend monthly clinic visits over a 12-month period

Who may not be able to join:

• People who have previously received any radiation therapy to the whole brain or part of the brain at any time
• People who currently have an active cancer elsewhere in the body that requires ongoing cancer treatment
• People who have an implanted medical device that is not compatible with radiation therapy, such as a pacemaker, cochlear implant, or deep brain stimulator
• People whose brain MRI shows certain concerning findings, including more than 4 small bleeds, more than 1 area of a specific type of surface bleeding, severely damaged white matter, or any larger bleed or blood stain greater than 10mm (confirm with trial site)
• People with a known active condition involving inflammation related to amyloid protein buildup in the brain's blood vessels, whether confirmed by biopsy, fluid analysis, or brain imaging
• People currently in the acute (active flare) phase of an autoimmune brain condition — those in a stable chronic phase may still be considered
• People with an uncontrolled infection or active blood poisoning (sepsis) at the time of joining
• People with severe, active psychiatric conditions such as psychosis or active suicidal thoughts that could affect their safety or ability to follow the study procedures
• People who are already enrolled in another interventional clinical trial targeting memory decline or brain inflammation
• People who are pregnant or breastfeeding; women who could become pregnant must use adequate contraception
• People who are unable to lie flat and still for approximately 10 to 15 minutes during each radiation session
• People whose MoCA score is below 10, indicating severe dementia

Important: Always verify eligibility with the trial site directly before applying.