Phase 2 Lung Cancer Trial, Terminated NCT00528775 Sponsor: Roswell Park Cancer Institute Condition: Lung Cancer
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Trial results

AI generated results summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

According to the results reported on ClinicalTrials.gov, this trial involved six people in a single group, all of whom received a treatment called HPPH (a type of light-sensitive drug used in photodynamic therapy, where a drug is activated by light to target tumour cells). Five participants completed the trial, while one did not finish. The trial was set up to measure how tumours responded to the treatment, as well as a range of secondary measures including symptom relief, how much of the drug concentrated in the tumour, and certain biological changes in tumour cells detected through laboratory tests. The reported data shows that while the trial did record these outcome measures — including tumour response, symptom changes using something called the Pulmonary Symptom Scale, drug concentration in tumour tissue, and laboratory markers of cell activity — no numerical results were included in the data submitted to ClinicalTrials.gov for any of these outcomes. In other words, the specific numbers that would normally describe what was found have not been reported in the structured results section of the registry. Because no measurement data was provided for any of the primary or secondary outcomes, it is not possible to describe what the trial found in numerical terms. These are the results as reported to ClinicalTrials.gov. They are not medical advice — always discuss what they mean for you with your doctor.

These are the results as reported to ClinicalTrials.gov, not medical advice. Verify independently with the trial site and discuss what they mean for you with your doctor.

Phase 2 Lung Cancer Trial, Terminated

NCT00528775
Terminated Phase 2

voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice

Who may and may not be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who may be able to join

  • You have been diagnosed with advanced non-small cell lung cancer that is blocking an airway, confirmed by a tissue sample (biopsy)
  • Your cancer type is squamous cell carcinoma, adenocarcinoma, or large cell carcinoma
  • You are not able to have surgery, or you have chosen not to have surgery
  • Your cancer has come back in the airway after previous surgery, radiation, or chemotherapy
  • You are well enough to carry out some daily activities (your doctor will assess your general health level)
  • Your blood cell counts, liver, and kidney function are within acceptable ranges (your doctor will check these)
  • Your blood clotting ability is within an acceptable range
  • You have had any previous cancer treatments, as long as chemotherapy or radiation finished at least 4 weeks before joining the trial
  • You are not pregnant or breastfeeding, and if you could become pregnant, you have had a negative pregnancy test

Who may not be able to join

Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.

  • Your scans show the tumor is wrapping around major blood vessels in the lungs
  • You have a complete blockage of the upper airway and need emergency treatment to open it right away
  • You have a known sensitivity or allergic reaction to porphyrin or similar compounds, or a condition called porphyria
  • You have severe chronic obstructive pulmonary disease (a serious long-term lung condition) that would make it unsafe to have multiple bronchoscopies (a procedure to look inside the airways)
  • You have a partial blockage of a central airway caused by mucus or debris build-up
  • You have a severe blockage at the top of your windpipe (trachea)
  • You are currently receiving chemotherapy or radiation therapy
  • You have any condition that makes a bronchoscopy (airway examination procedure) unsafe for you
  • You have underlying lung disease that means your lungs may not cope well with mucus or debris that can form after treatment (the lead doctor on the trial will assess this)
  • You are pregnant or breastfeeding
  • You are able to have children and are unwilling to use effective contraception during the trial and for 3 months after treatment ends

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 2 July 2026

GP referral letter

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Trial details

Status
Terminated
Phase
Phase 2
Registry
ClinicalTrials.gov
Start date
1 August 2007
Est. completion
1 November 2009

Where this trial was run

🇺🇸 United States

These are the locations recorded on the registry, and they are a historical record: this trial is not enrolling, so they are not places you can join it.

Primary endpoints

Tumor Response

Other options

Expanded access pathways

This trial is not enrolling. Other access pathways exist in general: in Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients. Whether it applies to any treatment studied here is a question for your doctor — nothing on this page says it does.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 2 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov