Phase 3 Pancreatic Cancer Trial, Completed

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with pancreatic cancer (specifically adenocarcinoma) that has spread to other parts of the body (metastatic), confirmed by a tissue or cell sample
• Your diagnosis of metastatic disease was made no more than 6 weeks before joining the study
• At least one of your tumors that has spread can be measured by a CT scan or MRI
• You are 18 years of age or older, and male or non-pregnant and non-breastfeeding female
• If you could become pregnant, you must have a negative pregnancy test within 72 hours before starting the study drug, and you must agree to use contraception during and after treatment
• You have not had any previous chemotherapy, radiation, or surgery for your metastatic disease (some prior treatments in an earlier stage setting may be allowed — confirm with trial site)
• Your blood counts (white cells, platelets, and hemoglobin) are at acceptable levels, tested within 14 days before joining
• Your liver, kidney, and other blood chemistry results are within acceptable ranges, tested within 14 days before joining
• Your blood clotting tests are within normal range, tested within 14 days before joining
• Your urine test shows no significant abnormalities, tested within 14 days before joining
• You are in reasonably good general health, as measured by a standard performance scale (Karnofsky score of 70 or above)
• You do not have yellowing of the skin (jaundice) at the start of treatment, any significant fluid buildup in your abdomen has been drained, and your pain is stable and not needing recent changes in pain medication
• You have read and understood the study information and have signed a consent form agreeing to take part

Who may not be able to join:

• You have cancer that has spread to the brain, unless it was treated successfully and has been stable for at least 3 months with no swelling and no steroid use
• Your cancer has not spread beyond the pancreas area and is only locally advanced (not metastatic)
• Your general health score dropped by 10% or more between your first assessment and within 72 hours before joining the study
• Your blood protein (albumin) level dropped by 20% or more between your first assessment and within 72 hours before joining
• You have had another cancer in the last 5 years (some exceptions apply for certain early-stage or skin cancers — confirm with trial site)
• You take the blood-thinning medication Coumadin (warfarin)
• You have an active, uncontrolled infection (bacterial, viral, or fungal) that requires treatment
• You have a known history of HIV, hepatitis B, or hepatitis C
• You have had major surgery within 4 weeks before the study start date (diagnostic biopsies without organ removal may be acceptable — confirm with trial site)
• You have a known allergy or bad reaction to any of the study drugs or their ingredients
• You have a history of connective tissue diseases such as lupus, scleroderma, or arteritis
• You have a history of lung disease affecting the lung tissue (interstitial lung disease)
• You have a history of chronic leukemia (such as chronic lymphocytic leukemia)
• You have a high risk of heart problems, including a heart attack or coronary stenting in the past year
• You have a history of poor blood circulation in the limbs (peripheral artery disease)
• You have serious health problems affecting any major organ, or serious mental health conditions that could affect your safety or the study results
• You are currently taking part in another clinical trial
• You are unable or unwilling to follow the study procedures, or you plan to be away on vacation for 7 or more consecutive days during the study

Important: Always verify eligibility with the trial site directly before applying.