NCT02342704

Who might be able to join this trial:

For people with Multiple Sclerosis (MS):

• You must have a confirmed diagnosis of relapsing MS, with a disability score between 0.0 and 5.5 on a standard MS scale.
• If you are currently taking one of these MS medications (Betaseron, Rebif, Avonex, Copaxone, Extavia, Tecfidera, or Aubagio), you must have been on it for at least 6 months, have at least 9 lesions visible on a brain MRI, and have had at least 1 relapse in the last 6 months along with new lesions shown on a recent brain MRI (confirm with trial site).
• If you have a very active form of MS (whether or not you have taken any MS medication before), you must have had at least 2 severe relapses in the past 12 months and have new lesions visible on a recent brain MRI (confirm with trial site).

For healthy volunteers:

• You must be in generally good health, with no history of serious illnesses, confirmed by a physical exam and medical history.
• If you are able to become pregnant, you must be willing and able to use effective birth control for the entire duration of the study.
• You must not have had any drug or alcohol misuse problems in the past year.

Who may not be able to join:

For people with Multiple Sclerosis (MS):

• You have been diagnosed with Primary Progressive MS or Secondary Progressive MS.
• You have HIV, hepatitis C, or an active hepatitis B infection, or test positive for these at screening.
• You have previously been treated with the MS medications natalizumab or fingolimod.
• You have a current or past history of cancer, including blood cancers or solid tumours (except certain completely removed and cured skin cancers).
• You have a history of serious opportunistic infections or other significant major illnesses, as judged by the study doctor.
• You have had a significant infectious illness (such as pneumonia or blood poisoning) within the past month.
• You have had problems with drug or alcohol misuse in the past year.
• You have used certain immune-suppressing medications or received certain biological treatments within the past 12 months (confirm with trial site for the full list).
• You have had a heart attack, unstable chest pain, stroke, mini-stroke, or severe heart failure in the past 6 months.
• You are currently taking certain heart rhythm medications known as Class Ia or Class III anti-arrhythmic drugs (confirm with trial site for specific drug names).
• You are currently taking medications that slow your heart rate, such as certain blood pressure or heart medications (confirm with trial site for specific drug names).
• You have high blood pressure that is not controlled by your current medications.
• You have a history of severe lung disease, lung scarring, or severe chronic obstructive pulmonary disease (COPD).
• You have received a live vaccine within the 8 weeks before screening.

For healthy volunteers:

• You experience claustrophobia (fear of enclosed spaces) severe enough to prevent you from having a reliable MRI scan.
• You have a history of major illness, including neurological conditions, as determined by the study doctor.
• You have a metal implant or device in your body that is affected by MRI, such as a pacemaker, aneurysm clip, or implanted defibrillator, or any metal fragments in your body.
• You are currently pregnant, breastfeeding, or have a positive pregnancy test at screening.

Important: Always verify eligibility with the trial site directly before applying.