Phase 1 Depression and Anxiety Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults between 18 and 65 years of age
• People who are right-handed
• For the healthy volunteer (control) group: People who do not have major depression, confirmed by scoring 7 or below on a standard depression rating scale, and who have no personal history of depression based on reported history and medical records
• For the treatment-resistant depression group: People who have major depression confirmed by scoring 17 or above on a standard depression rating scale, and whose medical records show that at least 3 to 4 antidepressant treatments at adequate doses and durations have not worked, including at least one treatment during the current depressive episode
• People with a good command of the English language

Who may not be able to join:

• People who have been diagnosed with another significant mental health condition (other than major depression for the depression group), as confirmed by medical records and a structured clinical interview
• People with known neurological or serious medical conditions, including dementia, stroke, brain injury, Parkinson's disease, brain tumors, multiple sclerosis, seizure disorders, or severe heart or lung disease
• People currently taking any medication that acts on the central nervous system, as assessed by the study investigator
• People with a known condition that affects how the body processes or removes drugs, such as kidney or liver disease, as assessed by the study investigator
• People who are left-handed
• People who are not suitable for MRI scans, for example due to a history of claustrophobia or having metal implants in the body (as determined by an MRI screening tool)
• For the control group only: People currently using any psychiatric medications, antidepressants, or prescription or non-prescription drugs or herbal products intended to treat depression or anxiety
• People with a history of substance dependence or misuse within the past 12 months, based on reported history or a urine drug screen
• People who are able to become pregnant and are not using effective contraception
• People for whom nitrous oxide (the study drug) would be medically unsuitable, including those with: a collapsed lung (pneumothorax), a bowel obstruction, a blockage in the middle ear, raised pressure in the skull, a chronic deficiency in vitamin B12 or folate being treated with supplements, current pregnancy, or those who are breastfeeding
• People who are not able to provide informed consent
• People who, in the investigators' judgment, may face safety risks or difficulties participating for any other reason — for example, living more than 100 miles from the clinic

Important: Always verify eligibility with the trial site directly before applying.