Printed from Voxsanity (voxsanity.com.au) — NCT03032601 — Data sourced from ClinicalTrials.gov. Verify directly with the trial site before attending. Not medical advice.
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Multiple Sclerosis Trial, By Invitation
NCT03032601
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- People who have been diagnosed with relapsing-remitting MS or progressive MS, and who either do not plan to start any MS medication during the study, or are already on a stable MS medication (interferon, glatiramer, dimethyl fumarate, or teriflunomide).
- People aged 18 years or older, with no upper age limit.
- People who are physically independent and able to walk.
- Women who could become pregnant must have a negative pregnancy test before joining and must use effective contraception throughout the study; male participants whose partner could become pregnant must also use effective contraception.
- People who are able to complete all study visits and procedures in the greater Philadelphia area.
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People who have received intravenous (IV) steroid treatment in the past 90 days for a reason other than MS.
- People who have had brain surgery that could affect the results of the brain scan (FDG PET-MRI) used in the study.
- People who score 20 or lower on a standard short memory and thinking test called the Mini-Mental Status Examination.
- People who use a wheelchair or are bed-ridden and cannot walk independently.
- People who have certain brain abnormalities — such as a previous stroke, a brain tumour, or a blood vessel problem in the area being studied — that could make the brain scans difficult to interpret.
- People with a history of a head injury that caused them to be unconscious for more than 48 hours.
- People with a history of asthma that requires daily medication to manage.
- People with any medical condition or physical limitation that could reasonably be expected to interfere with the assessment of MS symptoms or with any of the study tests, including the PET-MRI scan.
- People with a significant psychiatric (mental health) disorder identified through their medical history or examination that would prevent them from completing the study.
- People who are currently misusing alcohol or drugs.
- Women who are pregnant or breastfeeding.
- People who are currently enrolled in another clinical trial or experimental therapy, or who have been in one within the past 30 days.
- People who are scheduled for surgery at any point during the study period.
- People who take certain medications that may interact with the study drug NAC — including some blood pressure medications, blood-thinning medications, diabetes medications, and nitroglycerin — will be assessed individually by the study doctor to determine eligibility (confirm with trial site).
- People with a history of pulmonary hypertension (high blood pressure in the lungs).
- People with any neurological, psychiatric, or medical condition that the study investigator determines could affect how a radioactive tracer used in the scan is distributed in the body or brain.
- People currently taking medications that the study investigator determines could affect how radioactive tracers are distributed in the body or brain.
- People whose body weight exceeds the weight limit of the scanning table.
- People with claustrophobia (fear of enclosed spaces) severe enough to prevent them from completing the imaging scans.
- People whose blood sugar (glucose) level could interfere with the FDG PET scan results.
- People with any other reason they cannot have an MRI scan, including having metallic objects in their body such as a pacemaker.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.
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Trial details
Status
By Invitation
Phase
Not Applicable
Sponsor
Thomas Jefferson University
Registry
ClinicalTrials.gov
Start date
5 January 2017
Est. completion
8 July 2027
Where this trial is recruiting
🇺🇸 United States
Primary endpoints
Changes in the metabolic activity in the brain, and improved parameters with regard to the inflammation associated with the active lesions based on both MRI and PET findings.
Can't join this trial?
Data last synced from ClinicalTrials.gov: 24 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.
Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.