Phase 2 Type 1 Diabetes Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People diagnosed with Stage III or Stage IV sarcoma, or sarcoma that has come back after previous treatment
• People aged 18 to 65 years old at the time of joining the trial
• People who have waited at least 4 weeks since their last chemotherapy or radiation treatment, and at least 1 week since any immune-suppressing medications (such as steroid hormones)
• People whose side effects from previous chemotherapy have been well managed
• People whose cancer cells test positive for a specific target (confirmed by laboratory testing)
• People with a general health and activity score of 50% or higher on a standard medical scale (confirm with trial site)
• People with a life expectancy of more than 6 weeks
• People whose blood cell counts meet the minimum required levels for white blood cells and platelets (confirm with trial site for exact values)
• People whose blood oxygen level is 90% or above when breathing normal room air
• People whose liver function tests fall within acceptable ranges, as determined by the trial doctors
• People whose kidney function tests fall within acceptable ranges, as determined by the trial doctors
• People whose own immune T cells can be successfully prepared at the required level for the treatment (confirm with trial site)
• People who are willing to sign a consent form agreeing to take part

Who may not be able to join:

• People whose disease is progressing very rapidly
• People currently receiving another new or experimental treatment
• People whose tumour may be blocking or at risk of blocking their airway
• People with a history of epilepsy or other conditions affecting the brain or nervous system
• People who need immune-suppressing medications due to graft-versus-host disease (a reaction sometimes seen after certain medical procedures)
• People with a history of a heart condition called long QT syndrome, or other serious heart disease
• People with an active infection that is not under control
• People with active hepatitis B, hepatitis C, or HIV infection
• People who have been taking steroid medications throughout their whole body (not inhaled) within the 2 weeks before joining
• People who have previously received any gene therapy treatment
• People whose kidney or liver function test results fall outside specific limits set by the trial (confirm with trial site for exact values)
• People with other serious uncontrolled health conditions that would prevent safe participation
• People who are pregnant or breastfeeding
• People who have previously had a bad reaction to the drug cyclophosphamide
• People whose sarcoma has spread to the brain or central nervous system
• People whose situation may present risks to their safety or interfere with the trial results (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.