Early Phase 1 Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with rectal adenocarcinoma (a specific type of rectal cancer), confirmed through laboratory testing of tissue.
• People whose cancer is considered suitable for surgery with the goal of removing it completely (curative resection).
• People whose rectal tumor is located no more than 12 cm from the opening of the anus, as measured by a camera examination of the bowel or an MRI scan.
• People whose cancer has spread to nearby lymph nodes only within the area that would be treated by radiation.
• People whose cancer can be measured or assessed through scans or clinical examination, as defined by the trial's guidelines.
• People with a general health and activity level rated as 0, 1, or 2 on a standard scale used in cancer trials (ECOG scale), meaning ranging from fully active to capable of self-care but unable to carry out physical work (confirm with trial site).
• People with Stage II or Stage III rectal cancer, assessed through a combination of physical examination, CT or PET/CT scans of the chest, abdomen and pelvis, and a pelvic MRI scan.
• People who have no known medical reasons preventing them from receiving standard chemotherapy and radiation treatment to the pelvis (for example, no known deficiency in an enzyme called DPD that affects how certain chemotherapy drugs are processed).
• People of childbearing potential who are willing to use adequate contraception during and after treatment, as directed by the treating medical team.
• People who are willing to sign a written consent form to participate in the trial.
• People who are willing to return to the trial site for all required study visits and assessments.

Who may not be able to join:

• People who have been diagnosed with inflammatory bowel disease (a long-term condition causing inflammation in the digestive tract, such as Crohn's disease or ulcerative colitis).
• People whose colorectal cancer has been identified as MSI-H (a specific genetic feature of the cancer) at the time of joining the trial.
• People whose rectal cancer has come back after previous treatment (recurrent cancer).
• People whose tumor is causing a blockage in the bowel that produces symptoms — though people who have already had a stoma (a surgical diversion of the bowel) created to manage this may still be considered eligible.
• People who have previously had radiation treatment to the pelvic area.
• People who are currently receiving active treatment for another separate invasive cancer.
• People who are unwilling or unable to have a pelvic MRI scan.

Important: Always verify eligibility with the trial site directly before applying.