Phase 2 Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with locally advanced or metastatic colorectal cancer, or another type of solid tumour cancer, confirmed through a tissue sample test.
• People whose tumour has tested positive for a specific genetic feature known as MMR deficiency or MSI-H (a marker related to how cancer cells repair their DNA).
• People who have at least one tumour that can be measured on a scan.
• People who are generally active and able to carry out daily activities, with a performance score of 0 or 1 on a standard medical scale (confirm with trial site).
• People who are expected to live for more than 12 weeks.
• People whose blood counts and organ function (such as liver and kidneys) are at adequate levels.

Who may not be able to join:

• People who have taken part in another clinical trial or used an experimental treatment or device within the past 4 weeks, or who have had specific anti-cancer treatment within the past 2 weeks.
• People who have not yet recovered from significant side effects caused by previous cancer treatments.
• People who have previously received a type of cancer treatment known as an immune checkpoint therapy.
• People who have had major surgery within the past 4 weeks.
• People who have another active or progressing cancer that has required treatment within the past 5 years.
• People who have active cancer spread to the brain or the lining of the brain or spinal cord.
• People who have an active autoimmune disease that has required medication to treat.
• People who have a known history of HIV infection.
• People who have signs of a lung condition called interstitial lung disease.
• People who have a known history of significant heart problems.
• People who are unwilling to use highly effective contraception throughout the study.
• People who have other serious or uncontrolled medical conditions that the trial doctor believes would make participation unsafe.

Important: Always verify eligibility with the trial site directly before applying.