Phase 1 Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 12 to under 85 years with Ewing sarcoma, or aged 18 to under 85 years with other cancer types included in the trial
• People with Ewing sarcoma that has spread, cannot be removed by surgery, has come back, or has stopped responding to treatment, and who have had 1 or 2 previous rounds of standard cancer treatment
• People with colorectal (bowel) cancer who have had 1 previous round of cancer treatment that did not include a drug called irinotecan
• People with colorectal cancer who have had 2 to 3 previous rounds of cancer treatment and have never received a drug combination called FTD/TPI
• People whose cancer can be measured on a scan, according to standard medical criteria
• People with adequate blood, liver, kidney, and clotting function, as assessed by the trial team
• People who are reasonably well and able to carry out daily activities, based on standard performance scoring scales used by doctors
• People with an estimated life expectancy of at least 12 weeks
• People for whom a stored tissue sample or a fresh cancer biopsy is available

Who may not be able to join:

• People who have previously been treated with a type of drug called a DR5 agonist
• People who have received any cancer treatment, including experimental treatments, within the 4 weeks before the trial starts (some exceptions may apply — confirm with trial site)
• People with a known allergy or sensitivity to the study drug INBRX-109 or to similar laboratory-produced antibodies
• People who have had radiotherapy within 4 weeks before the trial starts, or radiation directed at the liver within the past 12 months
• People who have had a bone marrow or stem cell transplant from a donor within the last 5 years (some exceptions may apply — confirm with trial site)
• People with a history of other cancers, either previous or current (some exceptions may apply — confirm with trial site)
• People with blood or bone marrow cancers
• People with active brain or nervous system tumours causing symptoms, or cancer that has spread to the brain or the lining around it (some exceptions may apply — confirm with trial site)
• People with a history or current evidence of multiple sclerosis or other conditions that damage the protective covering of nerves
• People with chronic liver disease, including fatty liver disease (people under 45 with fatty liver disease may be considered if their liver function meets the required level — confirm with trial site)
• People who have had an acute viral or toxic liver illness within the past 12 months
• People with a known history of hepatitis B, hepatitis C, or HIV infection
• People with known sensitivity or allergy to certain drugs used alongside the study treatment, depending on their cancer type (confirm with trial site for the specific drugs relevant to each cancer type)
• People who have had a significant heart event such as a heart attack, unstable chest pain, or stroke within the past 3 months
• People with a serious blood clot in a vein or lungs that has not been stable or resolved for at least 3 months
• People who have had major surgery within 4 weeks before joining the trial
• People who have had a serious infection requiring antibiotic treatment within the past 2 weeks
• There may be additional exclusion criteria not listed here (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.