Phase 4 Type 1 Diabetes Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are over 18 years old
• People who have been diagnosed with Type 1 diabetes
• People who are in good general health
• People whose fasting C-peptide level (a marker of insulin production) is below 0.7 ng/ml
• People whose blood sugar control (measured by HbA1c) is between 7.0% and 11.0%
• People who manage their diabetes with multiple daily insulin injections or an insulin pump
• People whose total daily insulin dose is at least 0.6 units per kilogram of body weight per day
• People whose insulin dose has stayed roughly the same (within 4 units) over the past three months
• People whose kidneys are functioning at a sufficient level, with an eGFR of 60 ml/min or above (confirm with trial site)
• People whose weight has been stable (within about 3 pounds) over the past three months
• People who do not take part in an excessively heavy exercise programme

Who may not be able to join:

• People who have Type 2 diabetes
• People whose daily insulin dose is less than 0.6 units per kilogram of body weight per day
• People whose fasting C-peptide level is above 0.7 ng/ml
• People whose HbA1c is below 7.0% or above 11.0%
• People whose kidney function is below an eGFR of 60 ml/min
• People who have blood detected in their urine
• People who are pregnant, breastfeeding, have a positive pregnancy test, or are planning to become pregnant within the next year
• Women of childbearing age who are not willing or able to use at least two barrier methods of contraception during the study
• People who have a serious disease affecting a major organ system, including: a current or past cancer diagnosis (including bladder cancer); heart failure or a history of heart disease; chronic liver disease or abnormal liver test results; a history of alcohol or drug misuse; chronic lung conditions such as COPD or asthma; a history of rheumatic disease; a history of chronic pancreatitis or surgery on the pancreas; a history of stroke or mini-stroke (TIA); planned surgery during the study period; a history of HIV or other conditions that affect the immune system; a history of organ transplantation; or current use of medications other than insulin that are known to affect blood sugar levels (such as prednisone)
• People who have advanced diabetic eye disease affecting the retina
• People who follow a ketogenic (very low carbohydrate) diet
• People who have been hospitalised in the past 6 months due to diabetic ketoacidosis, severe low blood sugar, or severely uncontrolled blood sugar
• People who are currently experiencing symptoms of poor blood sugar control, such as excessive thirst or frequent urination
• People who have had an allergic reaction to dapagliflozin or pioglitazone in the past

Important: Always verify eligibility with the trial site directly before applying.