Phase 3 Atrial Fibrillation Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who are at least 18 years old
- People who have had a bleed inside the brain (including bleeding into the brain's fluid-filled spaces), confirmed by a CT or MRI scan
- People who can be enrolled in the trial between 14 and 180 days after their brain bleed occurred
- People who have an irregular heart rhythm condition called atrial fibrillation or atrial flutter, confirmed by a heart trace (ECG) or a doctor's records
- People who are willing and able to sign a consent form, either themselves or through a legally authorised representative
- Women who are able to become pregnant must be using a highly effective form of contraception
Who may not be able to join:
- People whose brain bleed was caused by a stroke that turned into a bleed, or by bleeding into a brain tumour
- People who had a previous brain bleed in the 12 months before this one
- People with an active infection of the heart valves (infective endocarditis)
- People who clearly need blood-thinning medications for another reason, such as blood clots in the legs or lungs, or who need blood platelet-reducing medications for a recent heart stent
- People who have previously had, or are planning to have, a procedure to close off a part of the heart called the left atrial appendage
- People with a significant blood clotting disorder
- People with high levels of a kidney waste product in the blood, indicating reduced kidney function (confirm with trial site)
- People with active liver disease or significant liver problems, as measured by a specific liver scoring system (confirm with trial site)
- People with long-term low red blood cell counts or low platelet counts, as judged by the investigating doctor
- People who are pregnant or breastfeeding
- People with a known allergy to aspirin or apixaban
- People who are already taking part in another competing clinical trial
- People whom the investigating doctor believes cannot safely or actively participate in the trial
- People with persistently high blood pressure that is not under control (consistently at or above 180 mm Hg)
- People whose brain bleed was caused by an abnormal tangle of blood vessels (arteriovenous malformation) that has not yet been treated
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Kevin N Sheth, MD, Yale University
Phone: 443-615-4729
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Stroke or death
Can't join this trial?
Data last synced from ClinicalTrials.gov: 16 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.