Phase 2 Type 1 Diabetes Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who have been diagnosed with Type 1 Diabetes.
- People who have had diabetes for more than 5 years.
- People whose average blood sugar level (measured by a blood test called HbA1c) is 9% or below.
- People who are able to understand and agree to the study rules by signing a consent form.
Who may not be able to join:
- People with a history of heart attack, irregular heartbeat, heart failure, or reduced blood flow to the heart.
- People with a history of stroke or brain disease.
- People who have had blockages in their urinary tract or difficulty passing urine.
- People with serious liver disease.
- People with low levels of red blood cells (anaemia), specifically a haemoglobin level below 11 g/dL.
- Women who are pregnant, breastfeeding, or unable to use effective contraception during the study.
- People with uncontrolled mania or a current major depressive disorder.
- People who have previously had an allergic reaction or bad side effects from heparin (a blood-thinning medication).
- People who cannot safely take a medication called metoclopramide — this includes those with a known allergy to it, a blockage in the digestive tract, uncontrolled high blood pressure, a tumour called pheochromocytoma, seizure disorders, Parkinson's disease, use of certain psychiatric medications within the past 6 months, use of benzodiazepine medications within the past month, use of certain antidepressants (MAOIs) or opioid pain medications within the past 14 days, active alcohol or drug misuse, or use of other sedating medications (confirm with trial site).
- People who have taken part in another study looking at low blood sugar awareness or related conditions in the past 30 days.
- People who are currently using an unblinded real-time continuous glucose monitor (a device that shows live blood sugar readings).
- People who regularly need to take paracetamol (acetaminophen).
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Simon Fisher, MD, PhD, University of Kentucky
Phone: 859-562-0473
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change in Blood Glucagon; Change in Blood Epinephrine; Change in Blood Norepinephrine; Change in Blood Cortisol; Change in Blood Pancreatic Polypeptide; Change in Hypoglycemia Symptom Recognition
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.