Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

Part B (before surgery):

• People who have been newly diagnosed with colorectal cancer (confirmed by tissue testing) and are scheduled for surgery aimed at curing the cancer, with no signs of the cancer having spread to other parts of the body
• People whose tissue testing shows high-grade abnormal cells and whose scans suggest colorectal cancer may be present — though continued participation after surgery depends on the cancer diagnosis being confirmed by the pathology results
• People aged 18 or older
• People who are able to understand and agree to take part in the study
• People who are able to attend follow-up appointments as required

Part C (after surgery):

• People aged 18 or older
• People with confirmed high-risk stage II or stage III colon or rectal cancer who had surgery aimed at curing the cancer, with no signs of the cancer having spread — and who are planned to receive chemotherapy after surgery (specific staging and risk definitions should be confirmed with the trial site)
• People whose surgery successfully removed the entire tumour with clear margins (more than 1mm of clear tissue around the tumour)
• People whose blood counts and organ function meet the required levels for safe chemotherapy — including adequate white blood cell counts, platelet levels, haemoglobin, kidney function, and liver enzyme levels (confirm specific values with the trial site)
• People who have not had major complications after surgery that would prevent them from receiving chemotherapy, in the opinion of the treating doctor
• People who are assessed by an oncology team as suitable for chemotherapy, are able to have a blood sample collected after surgery, and can be enrolled within approximately 8–10 weeks after surgery
• People with a general health/activity level rated as 0–2 on a standard medical scale (meaning able to carry out daily activities, with varying levels of limitation)
• People who are able to understand and agree to take part in the study

Who may not be able to join:

Part B:

• People who are planned to receive chemotherapy before surgery — although chemotherapy combined with radiation therapy before surgery is permitted for rectal cancer patients
• People who have had another cancer diagnosis within the past 5 years — except for certain treated skin cancers, superficial bladder cancer, prostate pre-cancer, cervical carcinoma in situ, or other non-invasive cancers

Part C:

• People who have had another cancer diagnosis within the past 5 years, except for non-melanoma skin cancers and carcinoma in situ
• People who have had major complications after surgery, or other health conditions that the treating doctor considers would make chemotherapy unsafe
• People who are not planned to receive chemotherapy after surgery
• People who have a known allergy or medical reason preventing them from taking the planned chemotherapy drugs (capecitabine alone, or capecitabine combined with oxaliplatin)
• People whose planned chemotherapy involves a drug called 5-Fluorouracil (5-FU), either alone or combined with oxaliplatin

Important: Always verify eligibility with the trial site directly before applying.