Phase 1 Myeloma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing and able to give written consent to participate
• You are between 18 and 75 years old (possibly older if considered healthy enough by the doctors)
• You have been diagnosed with AML, ALL, DLBCL, Burkitt lymphoma, multiple myeloma, or high-risk MDS (a type of blood cancer or pre-cancer condition), based on specific medical guidelines
• Your cancer has come back, stopped responding to treatment, or continued to get worse, and there are no suitable standard treatments left available to you
• For a specific group in the trial (Cohort V): you have relapsed, recurring, or worsening AML or MDS, and you have received no more than 70% of the maximum lifetime dose of a certain type of chemotherapy drug called anthracyclines
• Doctors estimate you are likely to live for at least 8 more weeks
• You are well enough to carry out basic daily activities (confirm with trial site for exact fitness level required)
• Your cancer can be measured through blood tests, bone marrow tests, or scans
• Your heart is pumping normally, based on your hospital's standard measurements
• Your liver and kidneys are working well enough, based on specific blood test results (confirm with trial site)
• Your platelet count meets the minimum required level (this can be supported with a platelet transfusion if needed)
• You are able to swallow and take medication by mouth
• If you are a woman who could become pregnant, you have had a negative pregnancy test

Who may not be able to join:

• You are under 18 years old
• It has been less than 4 weeks since you last received chemotherapy (some specific lower-dose drugs may have a shorter waiting period — confirm with trial site)
• It has been less than 1 week since you finished radiotherapy given to manage pain or symptoms
• It has been less than 2 weeks since you had surgery (minor procedures to allow access, such as inserting a line, may be an exception)
• You have had a serious heart event such as a heart attack, stroke, unstable chest pain, or heart surgery in the last 6 months
• You have moderate to severe heart failure
• You have a history of, or have been found to have, certain abnormal heart rhythms (some types may be acceptable — confirm with trial site)
• You currently need medication to control heart rhythm, unless it is a stable dose of a beta-blocker or calcium channel blocker
• Your heart's electrical activity shows a specific abnormality on an ECG (QTc interval over 470ms)
• You are currently using the painkiller Fentanyl and cannot stop it at least 1 week before starting the trial
• You are taking antioxidant vitamins or a medication called Acetylcysteine and cannot stop them within 48 hours of starting the trial
• You are taking certain antidepressant medications and cannot stop them at least 3 weeks before starting the trial (confirm with trial site for specific drugs affected)
• You have another serious medical condition that could put you at higher risk or affect the trial results
• You have active cancer spread to the brain (if this was previously known but has been stable for at least 8 weeks, you may still be eligible — confirm with trial site)
• You have a known active hepatitis B or C infection (stable hepatitis B with antiviral medication may be acceptable — confirm with trial site)
• You have a known HIV infection
• You are pregnant or breastfeeding
• You are able to have children but are not using an effective method of contraception
• You have taken part in another clinical drug trial recently and not enough time has passed since your last dose (confirm with trial site for exact timeframe)
• You have a specific type of leukaemia called acute promyelocytic leukaemia (AML M3)
• You have an ongoing infection that is not under control
• You are unable to follow the study procedures as required
• You have significant nerve damage or nerve-related side effects in your hands or feet (grade 2 or higher — confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.