Depression and Anxiety Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are able to provide written consent to participate
• People who speak English fluently
• People who are not currently using drugs, based on their own reported history and/or a urine drug screen

Who may not be able to join:

• Women who are pregnant, currently breastfeeding, trying to become pregnant, or who think they might be pregnant, based on self-report and/or a urine pregnancy test
• People who have certain medical devices or conditions that make brain scanning (fMRI) unsafe, such as a heart pacemaker, metal particles in the body, metal clips in the head, a prosthetic heart valve, or severe claustrophobia (confirm with trial site)
• People who cannot fit comfortably inside the scanner
• People who have conditions that make a type of brain stimulation called TMS unsafe, including a personal or family history of epilepsy, metal implants in the head or neck, certain brain or nerve stimulation devices, a VP shunt, or a pacemaker
• People who are currently taking medications that may increase the risk of seizures (such as bupropion, varenicline, chlorpromazine, or theophylline) or medications that may reduce the effectiveness of the brain stimulation used in the trial, such as benzodiazepines
• People who have a current or ongoing serious or unstable physical health condition affecting the heart, liver, kidneys, lungs, hormones, nervous system, or blood
• People who are not right-handed, based on a handedness assessment or self-report
• People who have had a head injury that caused more than a brief loss of consciousness
• People with a history of cocaine or stimulant use (such as amphetamines or methamphetamine)
• People who have previously used dopamine-affecting medications, including methylphenidate or other stimulant medications
• People who currently use, or have used more than occasionally in the past year, any tobacco or nicotine products — including cigarettes, e-cigarettes, cigars, snuff, chewing tobacco, nicotine gum, or nicotine patches
• People whose answers on self-report questionnaires show significant inconsistencies

For the optional Ecological Momentary Assessment (EMA) part of the trial — additional criteria:

• People assessed as having more than minimal suicide risk during a clinical interview or on a standard suicide rating scale (a score above 3 on the C-SSRS)
• People with any physical or neuropsychiatric condition that may make walking or running difficult or impossible
• People who meet the criteria for a current psychotic disorder, bipolar disorder, or severe substance use disorder, based on a standard psychiatric interview
• People who have used psychiatric medications within the last six weeks

For people joining with a diagnosis of Major Depressive Disorder — additional criteria:

• People assessed as having more than minimal suicide risk during a clinical interview or on a standard suicide rating scale
• People with a depression symptom score of 11 or higher on the Beck Depression Inventory (BDI-II)
• People with a current or past diagnosis of certain psychiatric conditions, including organic mental disorder, schizophrenia spectrum disorders, delusional disorder, unspecified psychotic disorders, psychotic features alongside mood symptoms, bipolar disorder, substance dependence, or substance misuse within the last 12 months (excluding cocaine or stimulant misuse, which is covered by a separate criterion above)
• People who have not been free of psychiatric medications for the required period before joining — this does not mean anyone would be asked to stop their medications; this criterion only applies to people who had already stopped taking them for their own reasons (confirm specific timeframes with trial site)

For people joining as healthy controls — additional criteria:

• People with any current or past psychiatric illness, a close family member (parent, sibling, or child) with a psychiatric illness, or any current or past use of psychiatric medications
• People with a BDI-II score above 10
• People with a score above 1 on the SHAPS scale (a measure of reduced ability to feel pleasure) (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.