Depression and Anxiety Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing and able to give their consent to take part in a research study
• People who are 18 years of age or older, of any gender
• People who can speak and read English and/or French
• People whose main diagnosis is a major depressive episode without psychotic features in their current episode, confirmed by a specific psychiatric interview tool
• People whose depressive symptoms have not improved after trying at least one antidepressant at an adequate dose during the current episode
• People with at least moderate depression symptoms, as measured by a score of 15 or higher on a standard depression rating scale (the 17-item Hamilton Rating Scale for Depression)
• People who have been referred for repetitive TMS (rTMS) treatment by their treating doctor and have freely decided to go ahead with this treatment
• People who are able to attend and stick to the treatment schedule
• People who have been on a stable psychiatric medication (including prescribed cannabis) or talking therapy for at least four weeks before entering the trial
• People aged 65 or older who score at or above an education-adjusted threshold of 24 on a standard memory and thinking assessment (confirm with trial site)

Who may not be able to join:

• People who currently have, or have had in the past three months, a moderate-to-severe problem with substance use or alcohol dependence (as defined by DSM-5 criteria); mild cannabis or alcohol use in the past three months may still be permissible (confirm with trial site)
• People who are currently using illegal substances or recreational cannabis
• People who have a significant unstable medical or neurological condition that is not well controlled (for example, uncontrolled diabetes or kidney problems)
• People whose depression appears to have a physical or medical cause (for example, a thyroid condition), as determined by their referring doctor
• People who are at acute risk of suicide or whose life is at risk due to self-neglect
• People who are pregnant, breastfeeding, or planning to become pregnant during the course of the treatment
• People who have a specific medical reason why TMS cannot be safely used, such as a personal history of epilepsy or seizures, a metal implant in the head, or a pacemaker
• People who are unwilling to continue their current antidepressant medication during the trial
• People who are taking more than 1 mg of lorazepam (or an equivalent dose of a similar medication) per day
• People with any other condition that the trial investigators consider would affect their ability to complete the study (confirm with trial site)
• People who have already tried electroconvulsive therapy (ECT) during the current depressive episode and it did not work — though having had unsuccessful ECT in a past episode does not prevent participation

Important: Always verify eligibility with the trial site directly before applying.