Peripheral Neuropathy Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 22 and 80 years old
• You have been diagnosed with a long-term, hard-to-treat chronic pain condition, such as pain after an injury, pain after surgery (including phantom limb pain), shingles-related nerve pain, complex regional pain syndrome, facial pain, or pain caused by a stroke, multiple sclerosis, or radiation treatment
• You have had severe pain for 2 or more years that has not responded well to treatment
• Your average daily pain over the past 30 days has been rated higher than 6 out of 10
• Your pain level changes by at least 3 points on a 0–10 scale at different times
• You have tried at least two different types of pain medications without enough relief, with stable doses for at least 30 days before the study starts
• Two independent surgeons have confirmed that surgery cannot fix the cause of your pain
• You are able to speak and read English
• You are able to understand and agree to participate in the study
• You do not have significant memory or thinking difficulties (based on a standard assessment test)
• You showed detectable pain signals or responded positively during a test stimulation period (confirm with trial site)

Who may not be able to join:

• You have serious health conditions that would make surgery risky, such as uncontrolled high blood pressure, bleeding problems, severe diabetes, major organ failure, an active infection, a history of infections related to implanted devices, a weakened immune system, or a cancer diagnosis with a life expectancy of less than 5 years
• You have a pacemaker, defibrillator, implanted drug pump, heart lines, or any brain implants (such as aneurysm clips, shunts, cochlear implants, or other stimulators) that are not compatible with the study device
• You are pregnant or breastfeeding (women who could become pregnant will need a negative pregnancy test before any procedure)
• You are experiencing significant active depression, have attempted suicide in the past 12 months, are considered at immediate risk of suicide, or have another untreated or uncontrolled mental health condition that a psychiatrist feels would make participation unsafe
• You have had a substance abuse problem in the past 3 years
• You are unable to safely stop blood-thinning medications before and after surgery
• You have other implanted hardware that is not compatible with MRI or with the study equipment
• An MRI scan shows findings that suggest a different diagnosis or make surgery unsafe
• You have previously had brain surgery that destroyed brain tissue (ablative surgery)
• You have previously had deep brain stimulation surgery using a device not compatible with the study system
• You have a major neurological condition beyond the one causing your chronic pain, such as epilepsy or a degenerative brain condition, or you are unable to recharge the study device
• You need or are likely to need diathermy (deep heat therapy), electroconvulsive therapy (ECT), or transcranial magnetic stimulation (TMS)
• You have known allergies or sensitivities to materials used in the study device
• The lead researcher believes that your participation would significantly increase your risk or significantly reduce your chance of benefit from this treatment

Important: Always verify eligibility with the trial site directly before applying.