Phase 1 Pancreatic Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are 18 years of age or older, of any gender
• People who have been diagnosed with a specific type of pancreatic cancer (adenocarcinoma or adenosquamous carcinoma) that doctors consider possibly removable by surgery, either upfront or after initial chemotherapy and/or radiation treatment
• People whose kidneys, liver, bone marrow, and immune system are functioning at adequate levels based on blood tests taken within 28 days before joining the trial
• People whose general health and ability to carry out daily activities meet a minimum standard (confirm with trial site)
• Women who could become pregnant must agree to use highly effective contraception starting at least 30 days before the first vaccination and continuing for at least 12 weeks after the last vaccination
• Women who could become pregnant must have a negative blood pregnancy test before vaccination
• Men who could father children must agree to use condoms or other effective contraception during the trial and for 12 weeks after the last vaccination
• People who agree not to donate blood for up to 90 days after their last vaccination
• People who are willing and able to follow the trial requirements and sign a consent form

Who may not be able to join:

• People whose pancreatic cancer cannot be surgically removed or has spread to other parts of the body (stage IV)
• People with HIV who also have a detectable viral load
• People with active hepatitis B or hepatitis C infections (though certain people with past hepatitis B or C exposure without active infection may still be eligible — confirm with trial site)
• People with any active autoimmune disease, immune deficiency, or a history of a nerve condition called Guillain-Barré syndrome; people with certain skin conditions such as eczema, psoriasis, or vitiligo may still be eligible if their condition is mild, well-controlled, affects less than 10% of the body, and has not required strong treatments in the past 12 months (confirm with trial site)
• People receiving a chemotherapy regimen before surgery that does not meet standard treatment guidelines, as determined by the trial doctor
• Women who are pregnant, breastfeeding, or who could become pregnant but decline to follow the contraception requirements outlined in the trial; women must have been without a menstrual period for at least 12 months to be considered past childbearing age
• People who are unwilling or unable to follow the trial procedures or provide consent
• People with severe or uncontrolled medical conditions that the trial doctor believes would affect safe participation, including but not limited to thyroid problems, active autoimmune disorders, untreated viral hepatitis, or autoimmune hepatitis
• People who require ongoing treatment with steroid medications at a moderate-to-high dose (10 mg per day of prednisone or equivalent or more) or any other ongoing medication that suppresses the immune system

Important: Always verify eligibility with the trial site directly before applying.