Phase 2 Pancreatic Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

For people with lung cancer:

• People diagnosed with locally advanced non-small cell lung cancer (stage I–III) who are not able to have surgery, or those with stage IIIa who are planned for a combination of chemotherapy, radiation, and then surgery
• People aged 18 years or older
• People who are able to read and sign a consent form agreeing to take part
• People who have not used any tobacco products in the past 6 months

For people with pancreatic cancer:

• People aged 18 years or older
• People whose doctors estimate they have more than 3 months to live
• People who are able to understand and sign a written consent form
• People who have a confirmed diagnosis of pancreatic ductal adenocarcinoma (a specific type of pancreatic cancer), confirmed through tissue or cell testing
• People whose tumour has been confirmed by a CT scan of the abdomen done within 1 month before the first study visit
• People whose original biopsy tissue samples are available at the Department of Pathology at Massachusetts General Hospital
• People who have had or currently have another cancer, where that cancer or its treatment is unlikely to interfere with the safety or results of this study
• People who have their first study visit scheduled within 1 month before starting chemotherapy and radiation treatment (called neoadjuvant chemoradiotherapy)
• People who are already scheduled to receive chemotherapy followed by radiation as part of their standard care
• People who have surgery to remove part of the pancreas planned within 1 month after their post-treatment study visit
• People who are scheduled to have a CT scan of the abdomen within 1 month after completing their chemotherapy and radiation treatment, as part of their routine care

Who may not be able to join:

For people with lung cancer:

• People who have electrical implants in their body, such as a pacemaker or infusion pump
• People who have metal implants or objects in or on their body, such as surgical clips, artificial heart valves with metal parts, metal fragments, shrapnel, metallic tattoos anywhere on the body, tattoos near the eye, or metal items in clothing
• People who are pregnant or breastfeeding (a blood pregnancy test is required for women who could become pregnant before taking part)
• People who experience severe anxiety in enclosed spaces (claustrophobia)
• People who have already had a high level of radiation exposure from research studies in the past 12 months (above 50 mSv, as defined by the Radiology Department guidelines)
• People who are unable to lie still and comfortably inside the MRI-PET scanning machine
• People whose body weight is over 300 pounds (approximately 136 kg), due to the weight limit of the MRI table
• People whom the study doctors consider medically unsuitable to take part, based on screening or during the study
• People with a known history of lung disease other than lung cancer or smoking-related lung disease
• People who have had pneumonia or another serious breathing illness within 6 weeks before joining the study (confirm with trial site for how pneumonia is defined in this context)

For people with pancreatic cancer:

• People who have previously had radiation treatment to the upper abdomen
• People who have had a reaction to a specific MRI contrast dye called Gadoterate meglumine
• People who have been diagnosed with acute pancreatitis (sudden inflammation of the pancreas) within 6 weeks before the first study visit, based on clinical assessment or imaging
• People with serious ongoing illness that is not well controlled, or whom the study doctors consider medically unsuitable to take part
• People with a psychiatric illness or personal circumstances that would make it difficult to follow the study requirements
• People who have electrical implants in their body, such as a pacemaker or infusion pump
• People who have metal implants or objects in or on their body, such as surgical clips, artificial heart valves with metal parts, metal fragments, shrapnel, metallic tattoos anywhere on the body, tattoos near the eye, or metal items in clothing
• People whose kidney function test result (eGFR) was below 30 mL/min/1.73 m² within the past 90 days, indicating reduced kidney function
• People who are pregnant or breastfeeding (a blood pregnancy test is required for women who could become pregnant at each PET/MRI study visit)
• People who experience severe anxiety in enclosed spaces (claustrophobia)
• People who have already had a high level of radiation exposure from research studies in the past 12 months (above 50 mSv, as defined by the Radiology Department guidelines)
• People who are unable to lie still and comfortably inside the MRI-PET scanning machine
• People with a BMI (body mass index) above 33, due to the weight limit of the PET-MRI table

Important: Always verify eligibility with the trial site directly before applying.