Phase 3 Myeloma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

Part One (initial entry):

• You have been newly diagnosed with multiple myeloma and are considered suitable for high-dose chemotherapy and a stem cell transplant
• You are between 18 and 74 years old at the time of signing the consent form
• Your multiple myeloma is detectable through specific blood tests measuring abnormal proteins at levels defined by international guidelines
• You are willing and able to give written consent to participate voluntarily
• You are generally able to carry out daily activities with little or no limitation (confirm with trial site regarding your specific activity level)
• You are willing and able to attend all required appointments and follow the study rules
• If you are a woman who could become pregnant, you must have a negative pregnancy test within 7 days before joining
• If you are a woman who could become pregnant, or a man who is sexually active with someone who could become pregnant, you must agree to use highly effective contraception during the study and for at least 28 days after the last dose of study medication — men must also not donate sperm during this time

Part Two (continuation):

• Your myeloma has reached a very deep level of response (no detectable cancer cells found in a bone marrow test) after your first treatment in Part One
• You completed your first-line treatment within Part One of this study
• You are still generally able to carry out daily activities with little or no limitation

Who may not be able to join:

Part One:

• You have already received more than one cycle of treatment for your multiple myeloma
• You currently have an active serious infection, active hepatitis B or C, or are known to be HIV positive
• You have another medical or mental health condition that would make the high-dose treatment or stem cell transplant unsafe, or that would make it hard for you to follow the study requirements
• You have another active cancer that is considered more life-threatening than your myeloma
• You are a woman with a positive pregnancy test during the screening period
• You are a woman who is currently breastfeeding and are not willing to stop before your first treatment cycle begins
• You have a known allergy to any of the study medications or their ingredients

Part Two:

• You have another active cancer that is considered more life-threatening than your myeloma
• You have a known allergy to any of the study medications or their ingredients

Important: Always verify eligibility with the trial site directly before applying.