Depression and Anxiety Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are between 18 and 70 years old
- You have been diagnosed with Major Depressive Disorder (a form of clinical depression) and are currently going through a depressive episode, without any psychosis (losing touch with reality)
- Your depression has been rated as moderate to severe based on a standard clinical questionnaire called the MADRS
- Your depression has not fully responded to between 1 and 4 antidepressant medications tried during your current episode
- If you are currently taking psychiatric medications, you are willing to keep that same medication routine unchanged during the study scanning period
- You are willing and able to have a non-invasive brain stimulation procedure done
- You are able to attend research appointments over approximately 8 weeks
- You are willing and able to give your informed consent to take part
- You are able to speak and read English
Who may not be able to join:
- You have been diagnosed with a psychotic disorder such as schizophrenia or a related condition during your current depressive episode
- You have a neurological condition such as epilepsy, stroke-related disease, dementia, raised pressure in the brain, a history of repeated or serious head injury, or a brain tumour
- You have a magnetic-sensitive medical device implanted in or near your head, such as a pacemaker, vagus nerve stimulator, or any metal clips, coils, staples, or stents
- Your primary diagnosis during the current depressive episode is generalised anxiety disorder
- You have had problems with alcohol or substance misuse or dependence (other than caffeine) in the past 6 months
- You have a history of seizures
- You have any implanted medical hardware that is not compatible with MRI scanning or with the study equipment
- You are unable to attend the required daily study visits
- You are pregnant, planning to become pregnant, or currently breastfeeding
- You are unable to speak or read English
- You are unable to give informed consent
- You are currently experiencing active thoughts or plans of suicide, as assessed by the study team during the trial
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Andrew Krystal, MD, MS, University of California, San Francisco
Phone: 415-476-7439
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change in MADRS score from baseline to end of treatment; Change in resting state BOLD signal from baseline to end of treatment; Change in resting state EEG from baseline to end of treatment; Change in white matter integrity from baseline to end of treatment
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.