Early Phase 1 Myeloma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed (confirmed by lab testing of tissue) with a type of blood cancer that is either a certain type of leukemia (ALL) or lymphoma (NHL) with a specific protein marker called CD19, or a type of blood cancer called multiple myeloma (MM) with a marker called BCMA.
• Your cancer has come back or has not responded to treatment, meeting at least one of these situations: your cancer never went into remission after standard chemotherapy; remission lasted less than 12 months after your first treatment; one or more follow-up treatments have not worked; your cancer has relapsed two or more times; your cancer came back after a stem cell transplant; or cancer outside the bone marrow has not responded to radiation or chemotherapy.
• Your liver is functioning well enough, shown by blood test results within acceptable ranges for bilirubin, ALT, and AST (confirm with trial site for exact values).
• Your kidneys are functioning well enough, shown by a blood test result within an acceptable range for creatinine (confirm with trial site for exact value).
• A heart scan (echocardiogram) shows your heart is pumping blood effectively enough (at least 50% efficiency).
• You do not have an active lung infection, and your blood oxygen level in normal indoor air is at least 92%.
• Your doctor estimates you are likely to live for at least 12 more weeks.
• You are reasonably able to carry out daily activities, rated on a standard scale from fully active to capable of limited self-care (ECOG score of 0, 1, or 2 — confirm with trial site).
• If you are a woman who could become pregnant, you tested negative for pregnancy before starting and agree to use effective birth control for at least one year after receiving the treatment.
• You are willing to take part in the study and sign a consent form.

Who may not be able to join:

• You have a history of serious brain or neurological conditions, such as head trauma, loss of consciousness, epilepsy/seizures, or bleeding or blockages in the brain.
• You have a history of serious heart conditions, such as a dangerously abnormal heart rhythm or a prolonged QT interval shown on a heart tracing (ECG).
• You are currently pregnant or breastfeeding.
• You have a serious active infection (not including simple urinary tract infections or mild throat infections).
• You currently have an active hepatitis B or hepatitis C infection.
• You have been taking steroid medication (taken by mouth or injection throughout the body) within the two weeks before screening, unless you are only using inhaled steroids.
• You have previously received a CAR-T cell therapy or any other type of genetically modified T cell treatment.
• Your kidney or liver function test results are above certain levels that suggest these organs are not working well enough (confirm with trial site for exact values).
• You have other serious health conditions that are not under control and that may make this trial unsuitable for you.
• You have HIV.
• The trial doctors believe your situation could put you at increased risk or could affect the reliability of the trial results.

Important: Always verify eligibility with the trial site directly before applying.