Fibromyalgia Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

For people with fibromyalgia:

• A doctor has confirmed a fibromyalgia diagnosis using the 2011 American College of Rheumatology classification criteria
• Pain has been present on more than half of days during the past month
• Average pain over the past 7 days has been rated at least 3 out of 10 on a pain scale
• Willingness to avoid starting new medications or treatments for fibromyalgia during the study
• Being right-handed
• Able to travel to the study site to receive brain stimulation treatments five times per week
• Willingness and ability to complete all study procedures
• Able to give written informed consent

For healthy volunteers (comparison group):

• Being right-handed
• Pain rated less than 0.5 out of 10 on a pain scale over the past 7 days
• Willingness and ability to complete all study procedures
• Able to give written informed consent

Who may not be able to join:

For people with fibromyalgia:

• Having another autoimmune or inflammatory condition (such as rheumatoid arthritis or lupus) that also causes pain
• A history of head injury involving significant loss of consciousness
• Having nerve damage from a known cause that interferes with everyday activities
• Daily use of opioid painkillers or marijuana, or a history of substance abuse
• Currently taking stimulant medications such as those used for ADHD (for example, Adderall, methylphenidate) or wakefulness medications such as modafinil
• Currently taking part in another treatment trial
• Taking over-the-counter pain medications (such as anti-inflammatories) on the day of brain or imaging scans
• Having taken opioid painkillers within 48 hours before a brain or imaging scan
• Currently pregnant or breastfeeding (a pregnancy test will be done before scan sessions)
• Having a serious psychiatric illness such as active schizophrenia, major depression with thoughts of suicide, or substance abuse within the past two years
• Having metal implants, surgical clips, staples, or certain dental metalwork that would make brain stimulation or scanning unsafe
• Having detailed prior knowledge of the brain stimulation technique used in this trial, or having previously received this type of treatment, in a way that could affect study blinding
• Having any other factor that the study team determines would prevent safe or reliable participation in the study
• A history of vascular surgery on the lower limbs, or current circulation problems in the lower limbs
• Currently involved in workers' compensation claims, legal action, disability claims, out-of-court settlements, or receiving financial compensation related to fibromyalgia
• Unwillingness or inability to give written informed consent

For healthy volunteers:

• Meeting the criteria for a fibromyalgia diagnosis
• Having any ongoing medical condition, including psychiatric disorders such as psychosis or schizophrenia (based on self-report)
• A history of head injury involving significant loss of consciousness
• Having nerve damage from a known cause that interferes with everyday activities
• Daily use of opioid painkillers or marijuana, or a history of substance abuse
• Currently taking stimulant medications such as those used for ADHD, or wakefulness medications such as modafinil
• Currently taking part in another treatment trial
• Currently pregnant or breastfeeding (a pregnancy test will be done before scan sessions)
• Having metal implants or other factors that would make brain or imaging scans unsafe
• Taking over-the-counter pain medications on the day of a scan
• Having taken opioid painkillers within 48 hours before a scan
• A history of substance use disorder in the past 24 months (based on self-report)
• A history of vascular surgery on the lower limbs, or current circulation problems in the lower limbs
• Any other factor that the study team determines would prevent satisfactory completion of the study
• Unwillingness or inability to give written informed consent

Important: Always verify eligibility with the trial site directly before applying.