Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with rectal cancer (a specific type called adenocarcinoma), confirmed by a tissue sample test
• Your tumour has a specific genetic feature called "dMMR" or "MSI-H," identified through laboratory testing of your tumour tissue
• Scans show your tumour is located in the lower part of the rectum (below a certain internal boundary called the peritoneal reflection)
• Your cancer has not spread to distant parts of the body, based on CT and MRI scans
• You have no blockage in your bowel, or any blockage has already been relieved by a temporary colostomy (a surgical opening in the abdomen to redirect the bowel)
• You have never had surgery on your rectum before
• You have never had chemotherapy or radiation therapy before
• You have never received immunotherapy (such as anti-PD-1 or similar drugs) or other biological treatments (such as monoclonal antibodies) before
• After initial treatment within the trial, scans and tests show your tumour has completely responded (disappeared) — confirmed by imaging and tissue biopsy
• You are willing and able to sign a consent form agreeing to take part

Who may not be able to join:

• You have a serious heart condition, such as an irregular heartbeat requiring certain medications, significant coronary heart disease, a heart attack within the last 6 months, or moderate-to-severe heart failure
• You have high blood pressure that cannot be controlled with medication
• You have HIV, or currently have active hepatitis B or C infection
• You have active tuberculosis (TB), are currently being treated for TB, or were treated for TB within the past year
• You have another serious active infection
• Your cancer has spread to areas outside the pelvis
• You have significant blood disorders or major organ problems (confirm with trial site)
• You have previously had radiation therapy to the pelvis or abdomen
• You have more than one colorectal cancer or more than one primary cancer at the same time
• You have epilepsy that requires treatment with steroids or anti-epilepsy medication
• You have had another type of cancer within the past 5 years
• You have a history of serious drug misuse, or psychological or social conditions that could affect your participation or the study results
• You have an active autoimmune disease (such as lung inflammation, eye inflammation, bowel inflammation, liver inflammation, kidney inflammation, thyroid problems, or asthma requiring an inhaler) or a history of such conditions
• You have received any vaccine in the 4 weeks before joining the trial
• You regularly take immune-suppressing drugs or corticosteroids (steroid tablets) above a low dose threshold
• You are known or suspected to be allergic to any of the drugs used in this trial
• You have any unstable health condition that could put your safety at risk during the trial
• You are pregnant, breastfeeding, or able to have children but not using contraception
• You do not wish to sign the consent form

Important: Always verify eligibility with the trial site directly before applying.