Atrial Fibrillation Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 18 and 80 years old.
• People who have persistent atrial fibrillation (an irregular heart rhythm that is ongoing or has required an electrical shock to reset the heart), confirmed by a heart tracing (ECG) or similar test within the past year.
• People whose atrial fibrillation has not been controlled by at least one standard heart rhythm medication, or who could not tolerate that medication.
• People whose left atrium (one of the heart's chambers) is not significantly enlarged, based on a heart scan result (confirm with trial site).
• People who are legally able to make their own decisions and are willing to sign a consent form.
• People who are willing and able to attend all required follow-up appointments.
• People with a life expectancy of at least 2 years.

Who may not be able to join:

• People who have previously had a catheter-based or keyhole surgical procedure to treat atrial fibrillation.
• People whose atrial fibrillation is caused by an imbalance of body salts, a thyroid condition, or another reversible or non-heart-related cause.
• People who have a specific type of abnormal heart rhythm called CTI-dependent atrial flutter.
• People whose atrial fibrillation is related to a heart valve problem.
• People who have a pattern of atrial fibrillation that comes and goes (paroxysmal AF) rather than persisting continuously.
• People whose atrial fibrillation has been continuously present for more than one year (long-standing persistent AF).
• People with a body mass index (BMI) over 35.
• People with severe heart failure symptoms (classified as NYHA class IV), or whose heart's pumping function is significantly reduced (ejection fraction below 35%).
• People with moderate heart failure symptoms (NYHA class III), unless those symptoms are caused or made worse by the atrial fibrillation itself.
• People who have had a heart attack within the past 2 months.
• People with an active infection or sepsis, indicated by elevated infection markers or a fever above 38.5°C.
• People with a known significant narrowing of the carotid artery (a major neck artery) of more than 80%.
• People who are already scheduled for heart surgery for a reason other than atrial fibrillation.
• People who are pregnant, or people who could become pregnant and are not using adequate contraception.
• People who need heart rhythm medication to control a dangerous heart rhythm originating in the lower chambers of the heart.
• People who have a blood clot or abnormal mass inside the heart.
• People with other serious health conditions that would make general anaesthesia or heart surgery too risky (as determined by the treating doctor).
• People who have previously had radiation therapy to the chest area.
• People whose personal circumstances would make attending follow-up visits impossible.
• People for whom a catheter cannot be inserted through a blood vessel for the procedure.
• People who have previously had open chest (thoracotomy) surgery.
• People for whom a specific step of the catheter procedure (transseptal puncture) cannot be safely performed (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.