Phase 4 Hypertension Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are able to understand the study and agree to participate in writing.
• Adults aged 40 years or older.
• People who have worked in a job where they were regularly exposed to other people's tobacco smoke for at least 5 years — for example, flight attendants who worked on flights before smoking was banned on aircraft, or casino workers who worked in venues without smoke-free policies.
• People who have never smoked, or who smoked very little in the past — specifically, those with a total lifetime smoking history of less than 1 pack-year, and who have not smoked for at least 20 years at the time of joining the study.

Who may not be able to join:

• People who are unwilling or unable to give written consent or follow the study procedures.
• People who are pregnant, breastfeeding, or planning to become pregnant.
• People currently taking a type of blood pressure medication called an ACE inhibitor or an angiotensin receptor blocker (ARB).
• People who are known to have had a bad reaction to an ACE inhibitor or ARB in the past.
• People with a history of angioedema (a condition causing sudden swelling, often of the face or throat).
• People who have a medical reason that would normally require them to take an ACE inhibitor or ARB — such as a previous heart attack or a known heart muscle condition.
• People with low blood pressure — specifically, a systolic reading below 90 mmHg or a diastolic reading below 60 mmHg, whether sitting or standing.
• People with a known significant narrowing (greater than 70%) of the artery supplying one or both kidneys.
• People with reduced kidney function, based on a specific calculation of kidney filtering ability falling below a certain level.
• People who regularly use anti-inflammatory pain medications (such as ibuprofen or naproxen) — defined as using them 5 or more days per week for more than one month.
• People taking potassium supplements, or whose blood potassium level is at or above a certain threshold at the first study visit.
• People currently taking a type of water tablet (diuretic) that raises potassium levels.
• People with a history of significant heart disease, including conditions such as angina, symptomatic coronary artery disease, poorly controlled high blood pressure, heart failure, significant heart valve disease, congenital heart conditions, or certain heart rhythm problems.
• People with significant lung disease that could interfere with study procedures — such as moderate or severe asthma, COPD, emphysema, chronic lung scarring, or high blood pressure in the lungs.
• People with nerve or muscle conditions, or physical limitations, that would prevent them from doing exercise testing on a stationary bike or similar equipment.
• People with a notable history of recreational drug use (other than marijuana) — specifically, use within the last 30 years, or use more than once a month before that period.
• People who use marijuana more than once a week.
• People with other long-term health conditions that, in the study doctor's judgment, would interfere with completing the study.
• People who have missed screening appointments or shown other signs of being unlikely to follow the study schedule.
• People currently taking part in another interventional research study.
• People with a body mass index (BMI) below 15 or above 40.
• People who have a metal object in their body that is not safe for use in an MRI scanner — such as certain pacemakers or defibrillators — may not be able to take part in the MRI portion of the study.

Important: Always verify eligibility with the trial site directly before applying.