Depression and Anxiety Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People aged 65 years or older, whether they are currently in hospital or being treated as outpatients.
- People who have been diagnosed with unipolar depression (a form of depression without manic episodes) based on standard diagnostic guidelines, with a depression severity score of 17 or higher on a recognised rating scale called the HDRS-17.
- People whose depression has not improved after trying at least one full course of antidepressant medication, including the one they are currently taking.
- People who plan to continue their current antidepressant medication (which they have been taking for more than 6 weeks) at the same dose throughout the study period.
- People who take benzodiazepines (a type of calming or anxiety medication) at a dose no higher than the equivalent of 40 mg of diazepam per day, with the dose having been stable for at least 2 weeks if it was recently changed.
- People who are able to read, understand, and sign a consent form agreeing to take part in the study.
Who may not be able to join:
- People who have a psychotic condition, except where psychosis is part of their depression (confirm with trial site).
- People with a personal or close family history of seizures or epilepsy, any known factors that can lower the threshold for having a seizure (such as sleep deprivation or substance use), a previous head injury, or metal implants in the head area (such as aneurysm clips, shunts, brain stimulators, cochlear implants, or electrodes) — dental fillings are generally not included in this exclusion.
- People who have a cardiac pacemaker, neurostimulator, surgical clips, or other electronic medical devices in the body, or who have certain neurological conditions such as raised pressure in the brain, a brain tumour, a history of stroke or mini-stroke, a brain aneurysm, or any structural brain damage that raises the risk of seizures as detected by MRI.
- People with significant memory or thinking difficulties, or dementia, as measured by a standard cognitive test (a score below 24 on the Mini Mental State Examination).
- People who have made a suicide attempt in the 6 months before the study starts, or who are currently considered by the treating doctor to be at high risk of suicide, including those who answer "yes" to a specific question about having an active plan and intent to end their life on recognised suicide assessment scales.
- People who make any changes to their regular psychiatric medications during the study, as this would result in withdrawal from the trial.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Dieter Zeeuws, MD, Universitair Ziekenhuis Brussel
Phone: +324763459
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Clinical effect of adTMS (Changes in depression severity clinician-rated and self-report)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 8 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.