Depression and Anxiety Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Female participants of any ethnic background.
• Adolescents aged 14 to 18 years old.
• Those who can provide written agreement to participate, along with agreement from a parent or guardian for participants under 18.
• People whose first language is English, or who are fluent in English.
• People who are right-handed.
• People who own a personal mobile phone (used for a type of regular survey during the study).
• People who are in a specific part of their menstrual cycle (the follicular phase) at the time of the brain scan session.

For the depression group specifically, people who:

• Have been diagnosed with Major Depressive Disorder (MDD) according to a standard medical assessment.
• Have not taken any psychiatric medications for a set period of time before joining — the length of time varies depending on the medication (confirm with trial site for details on specific medications).

For the healthy comparison group specifically, people who:

• Have no current or past diagnosis of any psychiatric condition or substance use disorder.
• Have no close family members (parents, siblings, or children) with a history of depression, bipolar disorder, or psychosis.

Who may not be able to join:

• People with a history of a head injury that caused loss of consciousness.
• People with a history of seizures or a seizure disorder.
• People with a serious or unstable physical health condition affecting the heart, liver, kidneys, lungs, hormonal system, nervous system, or blood.
• People with a history of using cocaine, amphetamines, methamphetamine, or similar stimulant drugs.
• People with a history of using dopamine-affecting drugs, including methylphenidate (a medication used for ADHD).
• People currently using hormone replacement therapy, anabolic steroids, or hormonal contraception (such as the pill).
• People with clinical or test-confirmed signs of an underactive thyroid.
• People with a physical or neurological condition that could affect the results of a brain scan measuring blood flow.
• People who cannot safely undergo an MRI scan — for example, due to claustrophobia, a pacemaker, surgically implanted metal devices, cochlear implants, metal braces, or other metal in the body.
• People who are currently pregnant.
• People who test positive for certain substances on a drug test taken on the day of the scan (including stimulants, marijuana, benzodiazepines, opiates, and several others).
• People who have previously had electroconvulsive therapy (ECT).
• People for whom the study clinician considers participation to be unsafe due to thoughts of suicide.

For the depression group specifically:

• People whose depression diagnosis is considered to be caused by another condition, rather than being the primary diagnosis (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.