Phase 4 Atrial Fibrillation Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who have been identified as needing a left atrial appendage closure (a procedure to reduce stroke risk in people with an irregular heartbeat) based on French national medical guidelines.
- People aged 18 or older.
- People who have given written consent to take part in the trial.
- People whose case has been reviewed and approved by a multidisciplinary medical team — including heart specialists, neurologists, and other doctors — who have confirmed that blood-thinning medication is not a suitable option for them.
- People who are registered under the French social security system.
Who may not be able to join:
- People under 18 years of age.
- People for whom a double blood-thinning tablet combination is considered too risky by the doctor who decided blood-thinning medication was not suitable.
- People who have a blood clot already present in the part of the heart targeted by the procedure.
- People with a serious illness that means life expectancy is less than one year.
- People with a severe inherited bleeding disorder.
- People with a known allergy or sensitivity to aspirin or clopidogrel (common blood-thinning tablets), including those who have experienced asthma triggered by aspirin or similar medications, active stomach ulcers or a history of stomach bleeding related to these medicines, any condition affecting the blood's ability to clot, a condition called mastocytosis (where aspirin can cause severe reactions), severe liver disease, severe kidney disease (confirm with trial site), or uncontrolled severe heart failure.
- People who cannot have an MRI scan — for example, due to severe claustrophobia, inability to remain still during the scan, or having certain metal implants or medical devices inside the body such as a pacemaker, defibrillator, certain types of heart valve, metal fragments (especially near the eye), brain clips, a cochlear implant, an insulin pump, or a nerve stimulator.
- People who are under a legal guardianship or curatorship arrangement (a formal legal arrangement where another person manages their affairs).
- People who are pregnant or who could become pregnant.
- Women of childbearing age who are not using a highly effective form of contraception as defined by medical guidelines (such as the pill, implant, injection, intrauterine device, or surgical sterilisation).
- People with a known sensitivity or contraindication to iodine (confirm with trial site).
- People who are already taking part in another interventional clinical research study of the same category.
- People who are currently in an exclusion period related to a previous research study.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Zakaria JALAL, MD, University Hospital, Bordeaux
Phone: (0)5 57 65 64 65
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change from baseline of ischaemic lesions number at 3 months appearing on brain MRI scans
Can't join this trial?
Data last synced from ClinicalTrials.gov: 20 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.