Depression and Anxiety Trial, Recruiting NCT04824105 Sponsor: Medical University of South Carolina Condition: Depression and Anxiety
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Depression and Anxiety Trial, Recruiting

NCT04824105
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People aged 18 to 65 years old
  • People who have been diagnosed with an anxiety disorder (such as Generalized Anxiety Disorder, Panic Disorder, Social Anxiety Disorder, or Specific Phobia), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), or an adjustment disorder involving anxiety
  • People who are currently receiving or seeking mental health treatment
  • People who are able to read and understand a consent form and agree to take part
  • People whose first or main language is English

Who may not be able to join:

  • People with a current alcohol or drug use problem that is more than mild in severity
  • People who have ever been diagnosed with a psychotic disorder or bipolar disorder with manic episodes
  • People who have a neurological condition that would make a brain stimulation technique (called TMS) or brain recording unsafe — this includes a seizure disorder, a history of traumatic brain injury with loss of consciousness, or a degenerative brain disease such as Alzheimer's, Parkinson's, or Frontotemporal Dementia
  • People with a physical health condition that would make it too uncomfortable to sit or lie still for long periods
  • People with conditions or characteristics that make MRI scanning or brain stimulation (rTMS) unsafe — this includes having metal implants in the body, being currently pregnant, having claustrophobia (fear of enclosed spaces), being sensitive to loud noise, having a medical condition or taking treatments that lower the seizure threshold, or having a history of severe brain injury or seizures/epilepsy
  • People currently taking anticholinergic medications, antipsychotic (neuroleptic) medications, or sleeping/sedative medications (note: certain other medications such as SSRIs, cholinesterase inhibitors, or NMDA receptor antagonists may be permitted if the person has been on a stable dose for at least four weeks before joining — confirm with trial site)
  • People currently taking long-term opioid medications or substances
  • People currently taking naltrexone

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 8 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Phone: 8437928465

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Registry
ClinicalTrials.gov
Start date
26 June 2021
Est. completion
31 August 2026

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Change in Fear-Potentiated Startle Reflex; Change in Speed to Initiate Avoidance Behavior

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 8 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov