Atrial Fibrillation Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are 18 years old or older
- You have been diagnosed with or are suspected to have a serious infection, and have been started on antibiotics
- You need medication to keep your blood pressure stable (specifically norepinephrine or epinephrine) and have been on it for at least 1 hour
- You have a fast, irregular heart rhythm (coming from the upper chambers of the heart) with a heart rate of 110 beats per minute or more, lasting at least 5 minutes
- You (or your next of kin, or under emergency consent procedures) have given written agreement to take part
- You are covered by a social security/health insurance system (this applies mainly to patients in France — confirm with trial site)
Who may not be able to join:
- Your condition is very severe and requires very high doses of blood pressure medication (above a certain threshold — confirm with trial site)
- You have had heart surgery or a heart transplant in the past month
- You have a mechanical heart valve in the aortic or mitral position, or have a significantly narrowed mitral valve
- You have a structural heart defect from birth, other than certain minor ones (such as a bicuspid aortic valve, a small hole between the upper heart chambers, or a patent foramen ovale)
- You had a pre-existing fast, irregular heart rhythm condition before this illness that required long-term medication to manage it, or you have had this type of irregular rhythm permanently
- Your irregular heart rhythm started more than 48 hours ago (or more than 24 hours ago if you are already on blood pressure medication) — though in some cases, extra tests may allow participation (confirm with trial site)
- You have received an electrical shock to reset your heart rhythm, or been given certain heart rhythm or rate-controlling medications, in the 6 hours before joining the trial
- You have a known reason why you cannot take the medication amiodarone, such as a past bad reaction to it, certain thyroid problems, certain lung conditions, certain abnormal heart rhythm readings on an ECG, a pacemaker-related issue, severe liver problems, or allergy to iodine or amiodarone
- Your potassium level in your blood is too low (below 3 mmol/L)
- You are pregnant or breastfeeding
- You are not expected to survive your current illness, you are detained or under court-ordered psychiatric care
- You are already taking part in another clinical trial related to serious infection or heart rhythm problems
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Vincent LABBE, MD, Assistance Publique - Hôpitaux de Paris
Phone: 01 56 01 69 37
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
all-cause mortality (a hierarchical criterion); the duration of septic shock according to the Finkelstein-Schoenfeld method (a hierarchical criterion).
Can't join this trial?
Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.