Phase 1 Mesothelioma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with cancer that has spread to the lining of the abdomen (called peritoneal carcinomatosis), coming from mesothelioma, an unusual cell growth in the abdomen lining, or from appendix, colon/rectal, or ovarian cancer — confirmed by the NCI's pathology lab.
• Your cancer can be measured or tracked using standard imaging tools or a scoring system that assesses how far the cancer has spread inside the abdomen.
• A surgeon has assessed that your cancer can be largely or completely removed surgically, and the spread of cancer inside your abdomen falls below a certain level on a scoring scale (for appendix, colon/rectal, or ovarian cancer: score below 20 out of 39; for mesothelioma or related conditions: score 30 or below out of 39).
• You are 18 years of age or older.
• You are in good general health and able to carry out normal daily activities with little or no difficulty.
• Your blood, liver, and kidney function meet certain minimum health levels as measured by blood tests (confirm with trial site for exact values).
• If you are able to become pregnant or able to father a child, you must agree to use reliable contraception (such as hormonal methods, barrier methods, or abstinence) from before the study starts until 180 days after the last treatment.
• You are able to understand the study information and are willing to sign a consent form agreeing to take part.
• You are willing to also join a separate tissue collection study run by the same institution.

Who may not be able to join:

• Your cancer has spread to parts of the body outside the abdomen.
• You have received chemotherapy directly into the abdomen or other cancer treatments within the last 4 weeks before the study starts.
• You have had major surgery within the last 12 weeks before the study starts.
• You have had an allergic reaction to platinum-based chemotherapy drugs in the past.
• You have a condition called dihydropyrimidine dehydrogenase (DPD) deficiency, which affects how certain chemotherapy drugs are processed — this applies only if you have appendix or colon/rectal cancer (confirm with trial site).
• You have a serious uncontrolled illness, such as an active infection, uncontrolled heart failure, unstable chest pain, irregular heart rhythm, or a mental health or personal situation that would make it difficult to follow the study requirements.
• You are currently pregnant, as the study involves major abdominal surgery and chemotherapy drugs that could be harmful to an unborn baby; if you are breastfeeding, you would need to stop breastfeeding during treatment.
• You are HIV-positive with a detectable level of the virus in your blood despite taking HIV medications; if you are HIV-positive but your virus is undetectable on treatment, you may still be considered, but only after a specialist consultation (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.