Phase 2 Peripheral Neuropathy Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing and able to sign a consent form and follow the study requirements
• People aged 18 to 75 years old (inclusive) at the time of signing the consent form, of any gender
• People who have been diagnosed with a malignant solid tumour, confirmed by laboratory tissue or cell testing
• People who have previously received chemotherapy that included a type of drug called a taxane
• People who have nerve pain or numbness (called chemotherapy-induced peripheral neuropathy) rated at a certain level of severity, as measured by standard medical scales (confirm with trial site)
• People whose general physical functioning is rated at a certain level on a standard scale used by doctors (ECOG score of 0–2, meaning able to carry out daily activities with at most limited self-care ability — confirm with trial site)
• People with an expected survival of at least 3 months
• People whose blood counts, liver function, and kidney function meet specific levels shown in blood tests taken during screening
• Women who are not breastfeeding and have a negative pregnancy test result
• People who are able to use effective contraception from signing the consent form until at least 30 days after the last dose of the study treatment
• People who are already taking certain pain medicines (such as opioids, paracetamol, aspirin, or anti-inflammatory drugs) may still be considered, provided the dose has been stable for the two weeks before joining

Who may not be able to join:

• People who have a known allergy or sensitivity to duloxetine or any of its ingredients
• People who are currently taking other medicines known to affect serotonin (a chemical messenger in the brain) levels
• People who need to take a type of antidepressant called a monoamine oxidase inhibitor (MAOI)
• People who have active cancer that has spread to the brain or the lining of the brain
• People who have a type of eye condition called uncontrolled closed-angle glaucoma
• People whose nerve symptoms are caused by physical pressure on a nerve (such as from a tumour pressing on it)
• People who have a mental health condition, epilepsy, mania, depression with thoughts of suicide, dementia, or issues with alcohol or drug use that could affect their ability to follow the trial requirements
• People who have certain heart or cardiovascular conditions, including moderate-to-severe heart failure, unstable chest pain, a heart attack or stroke in the past 6 months, certain heart rhythm problems, a blocked major vein near the heart, abnormal heart electrical readings above certain thresholds, or high blood pressure not controlled by medication
• People with other medical conditions or history that could interfere with the trial results
• People where the trial doctor or sponsor believes taking part would not be in that person's best interest

Important: Always verify eligibility with the trial site directly before applying.