Early Phase 1 Peripheral Neuropathy Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People between 21 and 65 years old
• People who have not used cannabis for at least 30 days before joining
• People who have had lower back pain lasting three months or longer
• People who are not currently taking opioid medications
• Women who are able to become pregnant must not be pregnant or breastfeeding at the time of joining
• People who do not have any mental or neurological conditions that affect their ability to feel sensations or move normally
• People who have never been dependent on cannabis at any point in their life
• People who have no lifetime history of schizophrenia, bipolar disorder, panic disorder, or psychosis (as defined by DSM-IV criteria)
• People who have used cannabis containing THC at some point in the past two years
• People who agree not to use any cannabis outside of the study while participating
• People who agree not to use opioids or barbiturates while participating in the study
• People who agree not to drive within 4 hours after each use of inhaled cannabis during the study

Who may not be able to join:

• People with an active lung or breathing disease
• People who have had an allergy, bad reaction, or negative experience with cannabis in the past
• People whose urine drug test shows the presence of THC, barbiturates, opioids, oxycodone, or methadone
• People with a significant illness such as heart disease, diabetes, kidney disease, or liver disease
• People who currently have or have previously had a condition that affects the immune system, such as lupus, psoriasis, or multiple sclerosis
• People who currently have or have previously had a neurological condition, including Parkinson's disease, dementia, memory or thinking problems, a history of seizures, or a history of brain or head injury
• People who currently have a major psychiatric illness such as bipolar disorder, severe depression, psychosis, a substance use disorder, or schizophrenia
• People who currently have or have previously had thoughts of suicide or have made a suicide attempt
• People who have a known sensitivity to heat or cold stimulation on the skin (confirm with trial site)
• People whose resting blood pressure is above 140/90
• People whose resting heart rate is above 100 beats per minute
• People who are currently in prison
• People who are currently living in an institution (such as a care facility) (confirm with trial site)
• People who experience claustrophobia (fear of enclosed spaces)
• People who have any condition or implant that makes an MRI scan unsafe (confirm with trial site)
• People who have started any new pain management treatment within two weeks before enrolling, or who plan to start a new pain management treatment during the study
• People with a known history of fainting, loss of consciousness, or severe reactions related to blood draws or needle procedures

Important: Always verify eligibility with the trial site directly before applying.