Phase 4 Peripheral Neuropathy Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People aged 18 to 80 years old
- People who are scheduled to have one of these specific back surgeries: (1) a minimally invasive spine decompression procedure at two or more spinal levels (such as a discectomy, foraminotomy, or laminectomy); (2) a minimally invasive spinal fusion procedure called TLIF at one to three spinal levels, with or without additional decompression, for no more than three total spinal levels treated; or (3) a spinal fusion procedure through the front or side of the body (ALIF or LLIF) at one to three levels, combined with a minimally invasive fixation procedure from the back at the same levels
- People who are willing and able to give their informed consent to participate
Who may not be able to join:
- People who regularly use opioid pain medications at a daily dose equivalent to more than 30mg of morphine at the time of surgery (confirm with trial site)
- People who have an implanted pain-relief device, such as an intrathecal opioid pump, spinal cord stimulator, or dorsal root ganglion stimulator
- People with a known allergy to bupivacaine, clonidine, or similar local anaesthetic medications
- People whose reason for surgery is something other than degenerative spine disease, such as a tumour, infection, or injury
- People with moderate-to-severe chronic kidney disease (stage 3 or higher) or liver failure
- People who are currently pregnant
- People with a medical condition or mental health condition that would make it difficult to accurately assess pain levels around the time of surgery (confirm with trial site)
- People who are currently involved in an active Workers' Compensation legal claim
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: John O'Toole, MD, Rush University Medical Center
Phone: (888) 352-7874
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Inpatient opioid consumption
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.