HIV and AIDS Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are female
• You are between 15 and 24 years old at the time of joining the study
• You are living with HIV and your HIV viral load (the amount of virus in your blood) has been undetectable (fewer than 40 copies/mL) within the last 6 months — or, for one specific part of the study, you do not have HIV
• You are willing to have blood drawn every 4 to 12 weeks throughout the study
• You are able to give your agreement to participate in English or Kiswahili (younger participants may need a parent or guardian to also give consent)
• For the medication drug-level (PK) part of the study: you have been taking the study HIV medication for at least 4 weeks, and you have started or plan to use a specific hormonal contraceptive (an injection called DMPA or a contraceptive implant) for at least the required time period
• For the interview/qualitative parts of the study: healthcare providers, program staff, policymakers, or other relevant professionals aged 18 or older who can consent in English or Kiswahili may also be eligible to participate

Who may not be able to join:

• You are currently taking a combination of HIV medications that includes certain specific drug types together — such as a non-nucleoside reverse transcriptase inhibitor (e.g., efavirenz) combined with a protease inhibitor (e.g., atazanavir/ritonavir or lopinavir/ritonavir) or an integrase inhibitor (e.g., raltegravir or dolutegravir) (confirm with trial site)
• You are currently pregnant, plan to become pregnant, or are breastfeeding within the coming weeks or year (the exact timeframe depends on which part of the study you are joining)
• You have had unprotected sex in the last two weeks, or a urine pregnancy test shows you may currently be pregnant
• You are taking or plan to take any medications during the study that are known to interfere with the study HIV drugs or, in some parts of the study, with hormonal contraceptives
• For the contraceptive (PK) part of the study: you are currently using or plan to use any other form of hormonal contraception at the same time
• For the contraceptive (PK) part of the study: your body mass index (BMI) is 30 or above (a medical measure of body weight relative to height)
• You have an active Hepatitis B virus (HBV) infection based on specific blood test results (confirm with trial site for details on exactly which test results would affect your eligibility, as some people with past Hepatitis B exposure may still be eligible)
• Your liver enzyme levels (ALT) are more than 5 times the normal upper limit at the time of your screening blood test, which may suggest a liver problem
• Your kidney function marker (creatinine) in your blood is more than 2.5 times the normal upper limit at the time of your screening blood test, which may suggest a kidney problem

Important: Always verify eligibility with the trial site directly before applying.