Phase 2 Pancreatic Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You have been diagnosed with a specific type of cancer in the head of the pancreas (pancreatic adenocarcinoma, duodenal adenocarcinoma, ampullary adenocarcinoma, or a cyst-related cancer called IPMN with adenocarcinoma), confirmed by a specialist scan and tissue sample
• A team of medical experts has agreed that surgery to remove the tumour is a suitable option for you
• Before surgery, you show 2 or more signs that suggest a higher risk of a specific post-surgery complication (such as being male, having a BMI of 30 or above, having a small pancreatic duct, having excess abdominal fat, or having low muscle mass) — and this higher risk is also confirmed during the operation itself
• If you are a woman who could become pregnant, you have had a recent menstrual period and a negative pregnancy test, and you agree to monthly pregnancy testing during the chemotherapy part of the trial
• If you are a woman who could become pregnant, or a male participant whose partner could become pregnant, you agree to use highly effective contraception during chemotherapy and for a set period afterwards (6 months for women, 1 month for men)
• You are covered by a health insurance system
• You have read and signed a consent form agreeing to take part in the study

Who may not be able to join:

• You have a specific type of diabetes identified by a pre-surgery blood test showing very low insulin production (confirm with trial site)
• You have a known or strongly suspected inherited genetic condition linked to pancreatic cancer risk (such as familial pancreatic cancer, Lynch syndrome, Peutz-Jeghers syndrome, Li-Fraumeni syndrome, or several other hereditary conditions)
• Your cancer has been found in more than one area of the pancreas before surgery
• Your overall health or other medical conditions make major abdominal surgery unsuitable
• There is a medical reason why you cannot receive a specific procedure involving transplanting insulin-producing cells into a vein in your liver (confirm with trial site)
• You are currently receiving, or are planned to receive, chemotherapy before surgery (neoadjuvant chemotherapy)
• Your cancer has already spread outside the pancreas, as identified before or during surgery
• You would need complex reconstruction of major blood vessels as part of your surgery
• There are signs of inflammation of the pancreas linked to a bile drain that could interfere with the cell isolation process (confirm with trial site)
• You have a known infection or positive blood test for HIV, Hepatitis B or C, HTLV, or syphilis
• You currently have an active COVID-19 infection (positive PCR test) — in this case, the procedure would need to be rescheduled at least 30 days later
• You are pregnant or currently breastfeeding
• You have a complete deficiency of an enzyme called dihydropyrimidine dehydrogenase, which affects how the body processes certain chemotherapy drugs
• You are unable to understand the purpose, benefits, and risks of the study, or cannot give written consent
• You are unable to follow the full schedule of the trial
• You are not covered by a health insurance system
• You are currently detained, receiving certain types of psychiatric care, living in a care institution, or are in an emergency situation

Important: Always verify eligibility with the trial site directly before applying.