Depression and Anxiety Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing and able to give written consent before any study activities begin
• People who are being treated as outpatients (not currently admitted to a hospital)
• People who have been diagnosed with major depressive disorder (a serious form of depression) and are currently experiencing a depressive episode, without any symptoms of psychosis, as confirmed by a structured interview at screening
• People aged 18 to 65 years old at the time of screening
• People whose depression is rated as moderate to severe based on a standard depression rating scale (a score of 20 or higher on the MADRS) at screening
• People who have not started or increased any psychiatric medications in the 4 weeks before screening
• People who are able to follow the treatment schedule required by the study
• People who pass a specific adult safety questionnaire related to the treatment being studied (confirm with trial site)
• People who the study investigators believe can understand and follow the study requirements

Who may not be able to join:

• People who currently have a serious alcohol or drug use disorder, are experiencing withdrawal symptoms, or have completed a detox program within the past 3 months
• People who have a major unstable physical illness, active hepatitis B, hepatitis C, HIV, active COVID-19, a cardiac pacemaker, or an implanted medication pump
• People who have active thoughts of suicide, as identified through specific screening questionnaires at the time of screening
• People who have a current clinical diagnosis of autism, dementia, or intellectual disability
• People who are taking medications that are not permitted under the study protocol (the study doctor will review all medications)
• People who are pregnant or breastfeeding
• People who have ever been diagnosed with bipolar disorder (type I or II), depression with psychotic features, schizophrenia, schizoaffective disorder, schizophreniform disorder, delusional disorder, or who currently have psychotic symptoms
• People who have obsessive-compulsive disorder or post-traumatic stress disorder (current or within the past year) that is considered by a study investigator to be more impairing than their depression
• People who have a personality disorder that is considered by a study investigator to be more impairing than their depression
• People who have previously received the specific treatment being studied in this trial (confirm with trial site for details), as this could affect the blinding of the study
• People who have a significant neurological condition, including but not limited to: a history of seizures (except those caused by electroconvulsive therapy or childhood febrile seizures), a brain lesion, cerebral aneurysm, Parkinson's disease, Huntington's disease, multiple sclerosis, a serious head injury involving more than 5 minutes of unconsciousness, or poorly controlled migraines requiring ongoing preventive medication
• People who have a metal implant inside or near their head (such as aneurysm clips, brain stimulators, cochlear implants, or electrodes), or any other metal object near the head that cannot be safely removed
• People who are currently in psychotherapy but have not been in a stable and consistent therapy arrangement for at least 3 months before joining, or who expect their therapy to change during the study
• People who have a significant abnormal result on laboratory tests, in the opinion of the study doctors
• People who are currently taking medications that may reduce the effectiveness of the study treatment (confirm with trial site)
• People who have a significant hearing impairment that cannot be corrected and would prevent them from participating in interviews
• People who have an unstable health condition that, in the opinion of the study investigators, could be negatively affected by the study treatment — for example, poorly controlled diabetes, high blood pressure, or unstable angina
• People who have an untreated thyroid condition, or who take thyroid medication but have not been on a stable dose for at least 30 days before enrolling
• People who have any other condition that, in the opinion of the study investigators, could affect their ability to complete the study
• People whose hairstyle or head covering at the time of the treatment sessions would prevent proper contact between the electrodes and the scalp
• People who have any reason they cannot safely receive the study treatment or undergo an MRI scan — for example, a hip circumference greater than 180 cm or metal in the body

Important: Always verify eligibility with the trial site directly before applying.