Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 years or older
• People with suspected metastatic colorectal cancer (cancer that has spread from the colon or rectum to other parts of the body), either at the same time as the original diagnosis or later — but only if a biopsy is needed as part of their usual care
• People whose doctors have determined they are suitable for standard combination chemotherapy treatments (such as FOLFOX, FOLFIRI, or FOLFIRINOX, with or without targeted therapies based on specific tumour gene markers)
• People with colorectal cancer that has been confirmed by tissue testing (histology)
• People who have at least one measurable area of cancer spread, as assessed by standard imaging criteria (RECIST v1.1)
• People receiving chemotherapy with either a curative or palliative goal
• People for whom a specific test called an Oncogram® can be carried out
• People with a general health score of 2 or below on the WHO performance scale (meaning they are able to care for themselves but may not be able to do heavy physical activity)
• People with a life expectancy of more than 3 months
• People whose blood test results meet specific thresholds for white blood cells, platelets, and haemoglobin (confirm with trial site for exact values)
• People whose liver function, kidney function, and other blood markers fall within acceptable ranges as set by the trial (confirm with trial site for exact values)
• People who have not had prior chemotherapy, except for chemotherapy given around the time of surgery or after surgery that was completed more than 6 months ago
• People with adequate kidney function based on a standard calculation (confirm with trial site)
• People who are enrolled in a social security scheme (this requirement applies under the French healthcare system)
• People who have been fully informed about the trial and have signed a consent form

Who may not be able to join:

• People whose cancer spread to the liver could potentially be removed by surgery or a procedure through the skin, based on specialist team discussion
• People whose cancer has spread at a later stage (after the original diagnosis) and who do not need a biopsy as part of their standard care
• People who have had a heart attack, severe chest pain, heart bypass surgery, moderate-to-severe heart failure, stroke, or a mini-stroke within the 6 months before joining
• People with high blood pressure that is not controlled by medication (above 140/90 mmHg)
• People who have had a bowel fistula, a hole in the bowel, an abscess in the abdomen, or active bleeding in the digestive tract in the 6 months before treatment begins
• People with an active stomach or intestinal ulcer
• People with a serious open wound or bone fracture that has not healed within the past 3 months
• People who have recently had a major surgical procedure (other than a diagnostic biopsy or placement of a medical port)
• People who have had radiation therapy within 4 weeks before the start of treatment
• People who have had an organ transplant, are HIV-positive, or have another condition that significantly weakens the immune system
• People who have had chemotherapy previously, except if it was given around the time of surgery or after surgery and was completed more than 6 months ago
• People with ongoing and uncontrolled serious illness affecting the liver, kidneys, or lungs in the past 6 months
• People with pre-existing nerve damage affecting the hands or feet rated above level 1 on a standard medical scale (confirm with trial site)
• People with a lung disease involving scarring or inflammation of lung tissue
• People with a history of long-term diarrhoea, inflammatory bowel disease, or a bowel blockage that has not resolved with treatment
• People who have had another cancer in the past 5 years, except for properly treated non-spreading colon cancer, a certain type of skin cancer (basal cell carcinoma), or early-stage cervical cancer
• People currently in another clinical trial involving an investigational treatment, or who left such a trial less than 6 months ago
• People with a known allergy or medical reason why they cannot take the drugs used in this trial
• People with a known deficiency of an enzyme called dihydropyrimidine dehydrogenase, which affects how certain chemotherapy drugs are processed by the body
• People with certain abnormal heart rhythm measurements on an ECG (above specific thresholds for men and women — confirm with trial site)
• People with abnormally low levels of potassium, magnesium, or calcium in the blood
• People of childbearing potential who are not using at least two effective methods of contraception, as well as women who are pregnant or breastfeeding, or women who have not had a pregnancy blood test
• People who are legally detained or under guardianship
• People for whom regular medical follow-up during the trial would not be possible due to geographical, social, or personal circumstances

Important: Always verify eligibility with the trial site directly before applying.