Myeloma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must be 18 years of age or older.
• You must be well enough to carry out daily activities to a certain level — the exact level required depends on which part (module) of the trial you are joining (confirm with trial site).
• For Modules A, B, and C: You have been diagnosed with smoldering multiple myeloma, multiple myeloma, or plasma cell leukemia.
• For Module D: You have been diagnosed with a low-risk blood condition called MDS (myelodysplastic syndrome) and do not currently need blood transfusions.
• Your doctor has assessed that it is safe for you to take part in the study based on your overall health.
• You are able to understand and follow the study procedures and instructions.
• You must be willing to sign a written consent form before joining the study.
• For Modules A and D (Physical Activity): You have access to a personal computer or tablet with a camera, microphone, speakers, and internet connection.
• For Module C (Beta Blocker): You have newly diagnosed multiple myeloma that requires treatment, but you have not yet started that treatment.
• For Module C: If you are a woman who could become pregnant, you must have a negative pregnancy test before starting and agree to use reliable contraception during the study; men with partners who could become pregnant should also use contraception.
• For Module D: You have not needed a blood transfusion in the 8 weeks before enrolling and are either being monitored, or taking growth factor treatments or a drug called luspatercept only.

Who may not be able to join:

• You have serious health conditions that could put you at risk during the study, such as active infection, heart failure, unstable chest pain, irregular heartbeat, or serious lung disease.
• You have a mental health condition or personal circumstances that would make it difficult to follow the study requirements.
• You are unwilling or unable to follow the study plan.
• Your doctor feels that, for any reason, you are not a suitable candidate for the study.
• For Module A (Physical Activity): You currently have a painful broken bone caused by your disease, or serious instability of your bones or muscles that makes exercise unsafe.
• For Module A (Physical Activity): A bone scan has shown that your bones are too unstable to safely take part in physical activity (as assessed by an experienced surgeon).
• For Module B (Nutrition): Your body weight is too low, indicating signs of malnutrition (BMI below 18).
• For Module B (Nutrition): You are following a special diet prescribed by a doctor.
• For Module B (Nutrition): You have diabetes and are taking medication or insulin to control your blood sugar.
• For Module B (Nutrition): You have any other condition that means you should not restrict your food intake (confirm with trial site).
• For Module C (Beta Blocker): You are currently taking, or have taken in the last 3 months, a type of heart medication called a beta-blocker.
• For Module C (Beta Blocker): You have certain heart, lung, blood pressure, or other conditions that mean beta-blocker medication would not be safe for you — including very slow heart rate, heart block, uncontrolled heart failure, low blood pressure, severe asthma, uncontrolled diabetes, certain circulation problems, or if you have a pacemaker (confirm with trial site for full list).
• For Module C (Beta Blocker): You are currently pregnant or breastfeeding.
• For Module D: A heart specialist (cardiologist) has determined that your heart condition makes it unsafe for you to exercise.

Important: Always verify eligibility with the trial site directly before applying.