Atrial Fibrillation Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 years or older
• People who are able to read, understand, and sign a consent form agreeing to take part
• People who have been diagnosed with atrial fibrillation (an irregular heartbeat), whether it is permanent, long-lasting, or comes and goes
• People whose stroke risk score (called CHA2DS2VASc) is 2 or higher, as calculated by their doctor
• People who either have a medical reason they cannot take blood thinners, or whose bleeding risk score (called HAS-BLED) is 3 or higher

Who may not be able to join:

• People with serious mental health conditions, including dementia (of any cause), schizophrenia, schizoaffective disorder, or bipolar disorder
• People who have previously had an ischemic stroke (a stroke caused by a blood clot)
• People with a history of long-term heavy use of alcohol or other mind-altering substances (not including nicotine)
• People who are on long-term treatment with a type of medication called benzodiazepines (used for anxiety or sleep)
• People who have taken antidepressant medications within the 3 months before joining the trial
• People who have had a past infection of the brain or nervous system, including a condition called neuroborreliosis (a nervous system infection caused by tick bites)
• People diagnosed with Parkinson's disease
• People diagnosed with Huntington's disease
• People diagnosed with Creutzfeldt-Jakob disease
• People diagnosed with Pick's disease (a type of brain condition)
• People who have significant narrowing (more than 70%) in certain major arteries supplying the brain (confirm with trial site)
• People who have abnormalities such as narrowing, widening, tearing, or bulging in certain large arteries near the heart (confirm with trial site)
• People whose brain MRI shows advanced changes to blood vessels, rated at the highest level (grade 3) on a standard medical scale
• People who have a blood clot or tumour in the left upper chamber of the heart or its attached pouch
• People who have a blood clot in the left lower chamber of the heart
• People whose heart anatomy makes it not possible to use a closure device in a particular part of the heart (confirm with trial site)
• People who have a mechanical (man-made) heart valve
• People who have previously had open surgery to close a hole between the upper chambers of the heart
• People who have previously had a closure device used to seal a hole between the upper chambers of the heart
• People who currently have an active heart infection (infective endocarditis)
• People who have implanted devices or prostheses that are not safe for MRI scans, such as certain pacemakers or surgical clips in the brain
• People who have had surgery on their oesophagus (the tube connecting the throat to the stomach)
• People who have pouches or pockets in the wall of the oesophagus
• People who have enlarged veins in the oesophagus rated above grade 3
• People who are allergic to contrast dye used in medical scans
• People who have a medical reason they cannot take antiplatelet medications (a type of blood-thinning tablet)
• People who have been diagnosed with cancer and whose estimated survival is less than one year (confirm with trial site)
• People with a clinically confirmed underactive or overactive thyroid gland
• People who experience claustrophobia (fear of enclosed spaces, such as an MRI machine)
• People who are pregnant
• People diagnosed with AIDS
• People already taking part in another clinical drug trial
• People whom the trial doctor considers unsuitable for any other medical or personal reason

Important: Always verify eligibility with the trial site directly before applying.